Direct measurement of the rupture force of single pair of decorin interactions

Xuhui Liu, Ming Long Yeh, Jack L. Lewis, Zong Ping Luo

研究成果: Article

24 引文 斯高帕斯(Scopus)


Decorin is one important member of the family of small leucine-rich proteoglycans, which are widely distributed in connective tissues in the body such as tendon and ligament. Decorin may be responsible for collagen fibril connection in those tissues. A recent hypothesis suggests that decorin may bind to collagen with its core protein while binding to another decorin through the interaction with their glycosaminoglycan (GAG) chains. However, there is no direct evidence supporting this hypothesis to date. In this study, the interaction of decorin GAG chains was directly determined for the first time. The rupture force of single bonds between decorins (GAG chains interaction) was determined directly as 16.5 ± 5.1 pN using a laser tweezers/ interferometer single molecular nanomechanical testing system. This information can improve our understanding of the mechanical properties of connective tissues at the molecular level.

頁(從 - 到)1342-1345
期刊Biochemical and Biophysical Research Communications
出版狀態Published - 2005 十二月 23

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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