Direct quantification of the rupture force of single hyaluronan/hyaluronan binding protein bonds

Xuhui Liu, Jian Q. Sun, Michael H. Heggeness, Ming Long Yeh, Zong Ping Luo

研究成果: Article

10 引文 斯高帕斯(Scopus)

摘要

The non-covalent bond between aggrecan and hyaluronan is critical for maintaining the normal structure and function of the extracellular matrix in articular cartilage. The failure of this bond can cause the loss of aggrecan and destruction of the extracellular matrix of articular cartilage. In this study, the rupture force of the single bond between hyaluronan and hyaluronan binding protein - the complex of the hyaluronan binding region of aggrecan and link protein - was directly measured with a nanomechanical testing system as 40±11 pN. The results were compared to a theoretical prediction based on a smart version of the Monte Carlo simulation.

原文English
頁(從 - 到)23-27
頁數5
期刊FEBS Letters
563
發行號1-3
DOIs
出版狀態Published - 2004 四月 9

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

指紋 深入研究「Direct quantification of the rupture force of single hyaluronan/hyaluronan binding protein bonds」主題。共同形成了獨特的指紋。

  • 引用此