Diseases caused by enterovirus 71 infection

Ta Chung Lee, How Ran Guo, Huey Jen Jenny Su, Yi Ching Yang, Hsiao Ling Chang, Kow Tong Chen

研究成果: Review article同行評審

113 引文 斯高帕斯(Scopus)


The purpose of this review was to explore the epidemiology, pathogenesis, virology, and management of enterovirus 71 (EV71) infection. Published literature was surveyed by Medline using the keyword "EV71." The reported incidence of cases of hand-foot-mouth disease/herpangina varied from year to year; seasonal variations in incidence were observed, with a peak in incidence during the summer season. Most cases of hand-foot-mouth disease/herpangina hospitalized for complications occurred in children less than 5 years old. The brainstem was the most likely major target of EV71 infection. Different enteroviruses cocirculate in the community annually. The emergence of the EV71 epidemic in the Asia Pacific region has been associated with the circulation of 5 genetic lineages (genotypes B3, B4, C1, C2, C4) that appear to be undergoing rapid evolutionary changes. The relationship between the gene structure of the EV71 virus and the factors that ensure its survival, ease of transmission, and evasion of immunity is still unclear. EV71 central nervous system involvement causes serious clinical illness, death, and long-term neurologic and psychiatric disorders in young children. EV71 infection has emerged as an important public health problem. Vaccine development is recommended for the prevention of EV71 infection in the future.

頁(從 - 到)904-910
期刊Pediatric Infectious Disease Journal
出版狀態Published - 2009 10月

All Science Journal Classification (ASJC) codes

  • 兒科、圍產兒和兒童健康
  • 微生物學(醫學)
  • 傳染性疾病


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