摘要
The invention provides disintegrin variants, and more specifically to disintegrin variants which are selective .alpha.v.beta.3 integrin antagonists for treatment and prevention of .alpha.v.beta.3 integrin-associated diseases. The present invention also relates to pegylated proteins, including proteins comprising a disintegrin variant having an RGD motif variant .sup.48ARLDDL.sup.53. The invention also relates to the use of the polypeptides of the invention for the treatment and prevention of .alpha.v.beta.3 integrin-associated diseases.
| 貢獻的翻譯標題 | 去整合蛋白變異體及其醫藥用途 |
|---|---|
| 原文 | English |
| 專利號 | 8183201 |
| 出版狀態 | Published - 1800 |