Disruption of the gene (spo0A) encoding sporulation transcription factor blocks endospore formation and enterotoxin production in enterotoxigenic Clostridium perfringens type A

I. Hsiu Huang, Michael Waters, Roberto R. Grau, Mahfuzur R. Sarker

研究成果: Article同行評審

85 引文 斯高帕斯(Scopus)

摘要

This study identified a functional spo0A ORF in enterotoxigenic Clostridium perfringens type A. To evaluate the function of spo0A, an isogenic spo0A knock-out mutant was constructed. The spo0A mutant was unable to form endospores and produce enterotoxin, however, these defects could be restored by complementing the mutant with a recombinant plasmid carrying the wild-type spo0A gene. These results provide evidence that spo0A expression is essential for sporulation and enterotoxin production in C. perfringens.

原文English
頁(從 - 到)233-240
頁數8
期刊FEMS Microbiology Letters
233
發行號2
DOIs
出版狀態Published - 2004 4月 15

All Science Journal Classification (ASJC) codes

  • 微生物學
  • 分子生物學
  • 遺傳學

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