Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome

Chia Yih Wang, Wei Yi Chen, Pao Yen Lai, Bon chu Chung

研究成果: Review article

9 引文 (Scopus)

摘要

Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in the nucleus and the centrosome. SF-1 moves dynamically in the nucleus, and SF-1 location and activity are dynamically regulated by post-translational modifications. In the centrosome, SF-1 maintains genomic integrity by controlling centrosome homeostasis. SF-1 prevents centrosome amplification by restricting aberrant activation of centrosomal DNA-PK. Upon SF-1 removal, DNA-PK is activated and centrosomes are amplified. This leads to genomic instability and cell growth defects. These data indicate that SF-1 at both the nucleus and the centrosome contributes to cell growth control, but the mechanisms of SF-1 action in different locations are different.

原文English
頁(從 - 到)148-153
頁數6
期刊Molecular and Cellular Endocrinology
371
發行號1-2
DOIs
出版狀態Published - 2013 五月 22

指紋

Steroidogenic Factor 1
Centrosome
Cell growth
DNA
Transcription
Cytoplasmic and Nuclear Receptors
Amplification
Genes
Chemical activation
Cells
Defects
Growth
Genomic Instability
Gonads
Post Translational Protein Processing
Energy Metabolism
Reproduction
Homeostasis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

引用此文

Wang, Chia Yih ; Chen, Wei Yi ; Lai, Pao Yen ; Chung, Bon chu. / Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome. 於: Molecular and Cellular Endocrinology. 2013 ; 卷 371, 編號 1-2. 頁 148-153.
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Distinct functions of steroidogenic factor-1 (NR5A1) in the nucleus and the centrosome. / Wang, Chia Yih; Chen, Wei Yi; Lai, Pao Yen; Chung, Bon chu.

於: Molecular and Cellular Endocrinology, 卷 371, 編號 1-2, 22.05.2013, p. 148-153.

研究成果: Review article

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AB - Steroidogenic Factor 1 (SF-1, Ad4bp, NR5A1) is a nuclear receptor expressed mainly in the adrenals and gonads. It activates the transcription of genes in steroidogenesis, reproduction, and energy metabolism. In addition, it also regulates the growth and differentiation of adrenogonadal primodial cells. SF-1 resides in the nucleus and the centrosome. SF-1 moves dynamically in the nucleus, and SF-1 location and activity are dynamically regulated by post-translational modifications. In the centrosome, SF-1 maintains genomic integrity by controlling centrosome homeostasis. SF-1 prevents centrosome amplification by restricting aberrant activation of centrosomal DNA-PK. Upon SF-1 removal, DNA-PK is activated and centrosomes are amplified. This leads to genomic instability and cell growth defects. These data indicate that SF-1 at both the nucleus and the centrosome contributes to cell growth control, but the mechanisms of SF-1 action in different locations are different.

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