Distinct Immunogenetic Profiles of Chronic Lymphocytic Leukemia in Asia: A Taiwan Cooperative Oncology Group Registry Study

Chi Yuan Yao, Andreas Agathangelidis, Shih Sung Chuang, Hsiao Hui Tsou, Wei Lien Feng, Ta Chih Liu, Tsai Yun Chen, Yuan Bin Yu, Su Peng Yeh, Ming Yao, Chuan Cheng Wang, Johnson Lin, Wen Li Hwang, Jyh Pyng Gau, Wen Chien Chou, Tsu Yi Chao, Liang In Lin, Hwei Fang Tien, Paolo Ghia, Shang Ju Wu

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Asian patientswith chronic lymphocytic leukemia (CLL) exhibit immunoglobulin heavy variable (IGHV) gene repertoires that are distinct from those observed in Western populations, and a higher proportion of Asian CLL patients carry heavy loads of somatic hypermutations (SHM) within the B-cell receptor immunoglobulins (BcR IG). Due to the low regional incidence of CLL in Asia, only a limited number of studies had attempted to probe the phenomenon of BcR IG stereotypy in Asian populations. In this study, we analyzed the IGHV-IGHD-IGHJ gene rearrangements from a series of 255 CLL patients recruited in a nationwide, multicenter study in Taiwan. Our analysis revealed that the IGHV gene repertoire was characterized by evident biases, with IGHV3-7, IGHV4-34, and IGHV3-23 being the most frequent rearranged IGHV genes, and a higher proportion of cases carrying mutated IGHV. In terms of BcR stereotypy, the incidence of major subsets was less frequent in this cohort, with subsets #77 and #28A being the most common, while the incidence of minor subsets was approximately equivalent to that reported in the Western cohorts. With this study, we provide evidence that CLL in Asia is indeed associated with distinct immunogenetic characteristics regarding IGHV gene usage, SHM status, and BcR IG stereotypy.

原文English
頁(從 - 到)E803
期刊HemaSphere
6
發行號12
DOIs
出版狀態Published - 2022 12月 25

All Science Journal Classification (ASJC) codes

  • 血液學

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