Distinct Physiological Characteristics of Isolated Laryngopharyngeal Reflux Symptoms

Han Chung Lien, Chen Chi Wang, John Y. Kao, Hong Zen Yeh, Jeng Yuan Hsu, Shou Wu Lee, Chun Yi Chuang, Yung An Tsou, Jung Der Wang, Michael F. Vaezi, Chi Sen Chang

研究成果: Article

3 引文 斯高帕斯(Scopus)


Background & Aims: Patients with isolated laryngopharyngeal reflux symptoms (LPRS) defined as those without concomitant typical reflux symptoms (CTRS) are clinically challenging to manage due to unclear pathophysiology. We investigated esophageal physiology in patients with isolated LPRS and their response to proton-pump inhibitors (PPI) therapy. Methods: This is a multi-center observational study conducted in referral hospitals in Taiwan. Patients with predominant LPRS, but without common non-reflux causes, underwent esophageal manometry, 24-hr ambulatory esophagopharyngeal pH testing, and Bernstein test, followed by a 12-week esomeprazole 40 mg twice-daily treatment. Participants with pathological reflux were divided into the isolated LPRS group (ie, LPRS without CTRS, n = 40) and the CTRS group (ie, LPRS with CTRS, n = 66). Participants without pathological reflux or esophagitis (n = 132) served as the nonreflux controls. Results: The PPI-responsiveness was similar between the isolated LPRS group and CTRS group (63% vs 57%, P = .8), but lower in the nonreflux controls (32%, P = .005). Despite similar distal esophageal acid exposure time (P = .7) when compared to those with CTRS, the isolated LPRS group had a lower prevalence of both positive Bernstein test (P = .001) and ineffective esophageal motility disorder (P = .03), and fewer pharyngeal acid reflux episodes (P < .0001). Conclusions: Our findings indicate similar distal esophageal acid exposure and PPI-responsiveness between LPRS patients with and without CTRS. The lack of CTRS in the isolated LPRS group is likely due to esophageal acid hyposensitivity and fewer pharyngeal acid reflux episodes, thus implicating distinct pathophysiology of isolated LPRS from those with CTRS.

頁(從 - 到)1466-1474.e4
期刊Clinical Gastroenterology and Hepatology
出版狀態Published - 2020 六月

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Lien, H. C., Wang, C. C., Kao, J. Y., Yeh, H. Z., Hsu, J. Y., Lee, S. W., Chuang, C. Y., Tsou, Y. A., Wang, J. D., Vaezi, M. F., & Chang, C. S. (2020). Distinct Physiological Characteristics of Isolated Laryngopharyngeal Reflux Symptoms. Clinical Gastroenterology and Hepatology, 18(7), 1466-1474.e4. https://doi.org/10.1016/j.cgh.2019.08.064