Distribution of functionalized gold nanoparticles between water and lipid bilayers as model cell membranes

Wen Che Hou, Babak Yaghoubi Moghadam, Charlie Corredor, Paul Westerhoff, Jonathan D. Posner

研究成果: Article同行評審

63 引文 斯高帕斯(Scopus)

摘要

Lipid bilayers are biomembranes common to cellular life and constitute a continuous barrier between cells and their environment. Understanding the interaction of nanoparticles with lipid bilayers is an important step toward predicting subsequent biological effects. In this study, we assessed the affinity of functionalized gold nanoparticles (Au NPs) with sizes from 5 to 100 nm to lipid bilayers by determining the Au NP distribution between aqueous electrolytes and lipid bilayers. The Au NP distribution to lipid bilayers reached an apparent steady state in 24 h with smaller Au NPs distributing onto lipid bilayers more rapidly than larger ones. Au NPs distributed to lipid bilayers to a larger extent at lower pH. Tannic acid-functionalized Au NPs exhibited greater distribution to lipid bilayers than polyvinylpyrrolidone- functionalized Au NPs of the same size. Across the various Au NP sizes, we measure the lipid bilayer-water distribution coefficient (K lipw = C lip/C w) as 450 L/kg lipid, which is independent of dosimetric units. This work suggests that the nanoparticle-cell membrane interaction is dependent on solution chemistry and nanoparticle surface functionality. The K lipw value may be used to predict the affinity of spherical Au NPs across a certain size range toward lipid membranes.

原文English
頁(從 - 到)1869-1875
頁數7
期刊Environmental Science and Technology
46
發行號3
DOIs
出版狀態Published - 2012 2月 7

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 環境化學

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