Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity

Sio Hong Lam; Hui Kang Liu; Shih Yuan Chung; Jia Ling Chang; Mao Xuan Hong; Sheng Chu Kuo; Chih Chuang Liaw

doi:10.1021/acs.jnatprod.3c00114

Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity

Sio Hong Lam, Hui Kang Liu, Shih Yuan Chung, Jia Ling Chang, Mao Xuan Hong, Sheng Chu Kuo, Chih Chuang Liaw

藥學系

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

摘要

Seven previously undescribed diterpenoids, tinocrisposides A-D (1-4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12, 14-16, and 18 presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protective effects on β-cells.

原文	English
頁（從 - 到）	1437-1448
頁數	12
期刊	Journal of Natural Products
卷	86
發行號	6
DOIs	https://doi.org/10.1021/acs.jnatprod.3c00114
出版狀態	Published - 2023 6月 23

All Science Journal Classification (ASJC) codes

分析化學
分子醫學
藥理
藥學科學
藥物發現
補充和替代醫學
有機化學

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10.1021/acs.jnatprod.3c00114

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title = "Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity",

abstract = "Seven previously undescribed diterpenoids, tinocrisposides A-D (1-4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12, 14-16, and 18 presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protective effects on β-cells.",

author = "Lam, {Sio Hong} and Liu, {Hui Kang} and Chung, {Shih Yuan} and Chang, {Jia Ling} and Hong, {Mao Xuan} and Kuo, {Sheng Chu} and Liaw, {Chih Chuang}",

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T1 - Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity

AU - Lam, Sio Hong

AU - Liu, Hui Kang

AU - Chung, Shih Yuan

AU - Chang, Jia Ling

AU - Hong, Mao Xuan

AU - Kuo, Sheng Chu

AU - Liaw, Chih Chuang

PY - 2023/6/23

Y1 - 2023/6/23

N2 - Seven previously undescribed diterpenoids, tinocrisposides A-D (1-4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12, 14-16, and 18 presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protective effects on β-cells.

AB - Seven previously undescribed diterpenoids, tinocrisposides A-D (1-4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12, 14-16, and 18 presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protective effects on β-cells.

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Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity

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