Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

Chia Yu Cheng, Yu Fang Lai, Yu Ling Hsieh, Ching Hao Wu, Chi cheng Chiu, Yu Min Yang

研究成果: Article同行評審

摘要

Lipid-like ion-pair amphiphile vesicles, or catanionic vesicles, have emerged as potential drug carriers. The effects of cholesterol on the properties of catanionic vesicles have yet been systematically studied. Here, we compared the effects of cholesterol on the structures and fluidities of dipalmitoylphosphatidylcholine liposomes and catanionic vesicles with similar main transition temperatures (Tm). For liposomes, fluorescence anisotropy (FA) thermograms reveal typical condensing and disordering effects of cholesterol above and below Tm respectively. In contrast, FA and molecular simulation data reveal that catanionic bilayers below Tm are more fluidic due to shorter alkyl chains. This leads to only condensing effects of cholesterol for catanionic vesicles at all temperatures. Our results provide important insights into the fabrication of catanionic vesicles as novel drug carriers.

原文English
頁(從 - 到)1827-1838
頁數12
期刊FEBS Letters
596
發行號14
DOIs
出版狀態Published - 2022 7月

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

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