Do stress and long-term potentiation share the same molecular mechanisms?

Chiung Chun Huang, Chih Hao Yang, Kuei-Sen Hsu

研究成果: Review article

36 引文 (Scopus)

摘要

Stress is a biological, significant factor shown to influence hippocampal synaptic plasticity and cognitive functions. Although numerous studies have reported that stress produces a suppression in long-term potentiation (LTP; a putative synaptic mechanism underlying learning and memory), little is known about the mechanism by which this occurs. Because the effects of stress on LTP and its converse process, long-term depression (LTD), parallel the changes in synaptic plasticity that occur following the establishment of LTP with tetanic stimulation (i.e., occluding LTP and enhancing LTD induction), it has been proposed that stress affects subsequent hippocampal plasticity by sharing the same molecular machinery required to support LTP This article summarizes recent findings from ours and other laboratories to assess this view and discusses relevant hypotheses in the study of stress-related modifications of synaptic plasticity.

原文English
頁(從 - 到)223-235
頁數13
期刊Molecular Neurobiology
32
發行號3
DOIs
出版狀態Published - 2005 一月 1

指紋

Neuronal Plasticity
Long-Term Potentiation
Depression
Biological Factors
Cognition
Learning

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

引用此文

Huang, Chiung Chun ; Yang, Chih Hao ; Hsu, Kuei-Sen. / Do stress and long-term potentiation share the same molecular mechanisms?. 於: Molecular Neurobiology. 2005 ; 卷 32, 編號 3. 頁 223-235.
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Do stress and long-term potentiation share the same molecular mechanisms? / Huang, Chiung Chun; Yang, Chih Hao; Hsu, Kuei-Sen.

於: Molecular Neurobiology, 卷 32, 編號 3, 01.01.2005, p. 223-235.

研究成果: Review article

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