Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus

Tzuen Ren Hsiue, Yue Liang Leon Guo, Kuan Wen Chen, Chang Wen Chen, Cheng Hung Lee, Han Yu Chang

研究成果: Article

22 引文 斯高帕斯(Scopus)

摘要

Study objectives: To determine the dose-response aspect of pulmonary function impairment in patients with consumption of Sauropus androgynus for weight reduction. Methods: A questionnaire and pulmonary function tests were performed in 194 patients with a history of consumption of S androgynus with or without chest symptoms. Patients with obstructive ventilatory defect received follow-up spirometry 22 to 24 months after beginning consumption of the vegetable. Results: Data from 178 patients were analyzed. Patients generally consumed 150 g of S androgynus daily as raw juice (60.7%), sauteed (16.9%), mixed preparation (20.8%), or boiled (1.7%) for various periods of time. We divided patients into five groups according to the total dose consumed (group A, 0 to 1,799 g; group B, 1,800 to 3,599 g; group C, 3,600 to 5,399 g; group D, 5,400 to 7,199 g; and group E, ≤ 7,200 g). The frequency of obstructive ventilatory defect was higher in the high-dose group than in the low-dose group (A, 4/43=9.3%; B, 13/64=20.3%; C, 14/32=43.8%; D, 5/12=41.7%; and E, 13/27=48.1%; p<0.01). In total, 49 patients (27.5%) had moderate to severe obstructive ventilator), defects without bronchodilator response. The FEV1 and FEV1 percent predicted in these 49 patients were 0.96±0.38 L (mean±SD) and 41.8±16.9%, respectively. Sixty-five percent of these 49 patients began to suffer from dyspnea in the third, fourth, or fifth month after taking the vegetable and no patient began to develop dyspnea later than 7 months after beginning consumption of the vegetable. Using stepwise multiple regression, we found that the FEV1 percent predicted was negatively associated with the total dose ingested (r=0.24, p<0.01). Follow- up spirometry showed that the obstructive ventilatory defect was irreversible in all patients. Conclusions: Consumption of S androgynus can result in moderate to severe obstructive ventilatory defect within 7 months, and the disorder was irreversible in the observation period for 22 months.

原文English
頁(從 - 到)71-76
頁數6
期刊Chest
113
發行號1
DOIs
出版狀態Published - 1998 一月 1

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

指紋 深入研究「Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus」主題。共同形成了獨特的指紋。

  • 引用此