Dose-response relationships of propranolol in Chinese subjects with different CYP2D6 genotypes

Chin-Wei Huang, Ming Liang Lai, Min Shung Lin, Hwei Ling Lee, Jin Ding Huang

研究成果: Article

10 引文 斯高帕斯(Scopus)

摘要

Background. For clinical treatment, a smaller dosage of propranolol is often used among Chinese people. Propranolol is metabolized by polymorphic CYP2D6. We postulate that the lower propranolol dosage in Chinese is due to a slower CYP2D6 metabolism. A majority of the Chinese population has the nucleotide T188 in the CYP2D6 gene (CYP2D6*10) instead of C188 (CYP2D6*1), which most white subjects have. Chinese subjects of different CYP2D6*1/CYP2D6*10 genotypes have been shown to have different propranolol pharmacokinetic characteristics. In this study, we compared the β-blockade effects of propranolol in Chinese subjects of the two different CYP2D6 genotypes. Methods. Based on the nucleotide 188 genotypes, two groups of 10 healthy subjects each were selected. Each subject was given a 10-, 20-, or 40-mg rac-propranolol tablet three times a day for 3 days in 3 different phases. Heart rate and blood pressure were measured in both supine and upright positions. The heart rate was also determined during treadmill exercise test. Plasma concentration of S-propranolol at 2 hrs after the last-dose administration was measured. Results. Despite therebeing higher S-propranolol plasma concentration in CYP2D6*10 subjects than in CYP2D6*1 subjects at 10- and 20-mg dosage, the dose-response relationship was not significantly different in these subjects. Conclusions. Our results do not support the hypothesis that CYP2D6*1/CYP2D6*10 polymorphism may affect the β-blockade effect of propranolol in Chinese subjects.

原文English
頁(從 - 到)57-62
頁數6
期刊Journal of the Chinese Medical Association
66
發行號1
出版狀態Published - 2003 一月 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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