Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of nigrofomes melanoporus and their cytotoxicity

Hsiu Hui Chan, Shin Hun Juang, Tran Dinh Thang, Min Yu Chen, Ping Chung Kuo, Mei Lin Yang, Nguyen Thi Ngan, Nguyen Ngoc Linh, Tian Shung Wu

研究成果: Article

1 引文 斯高帕斯(Scopus)

摘要

Two new drimane-type compounds, nigrofomins A (1) and B (2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A (1) and B (2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC 50 values in the range of 99.44-246.32 μM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G 0/G 1 phase.

原文English
頁(從 - 到)737-739
頁數3
期刊Planta Medica
78
發行號7
DOIs
出版狀態Published - 2012

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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