Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics

King Chuen Wu, Kai Sheng Liao, Li Ren Yeh, Yang Kao Wang

研究成果: Review article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Cancer is one of the leading causes of death worldwide. There are only limited treatment strategies that can be applied to treat cancer, including surgical resection, chemotherapy, and ra-diotherapy, but these have only limited effectiveness. Developing a new drug for cancer therapy is protracted, costly, and inefficient. Recently, drug repurposing has become a rising research field to provide new meaning for an old drug. By searching a drug repurposing database ReDO_DB, a brief list of anesthetic/sedative drugs, such as haloperidol, ketamine, lidocaine, midazolam, propofol, and valproic acid, are shown to possess anti-cancer properties. Therefore, in the current review, we will provide a general overview of the anti-cancer mechanisms of these anesthetic/sedative drugs and explore the potential underlying signaling pathways and clinical application of these drugs applied individually or in combination with other anti-cancer agents.

原文English
文章編號1589
期刊Biomedicines
10
發行號7
DOIs
出版狀態Published - 2022 7月

All Science Journal Classification (ASJC) codes

  • 醫藥(雜項)
  • 生物化學、遺傳與分子生物學 (全部)

指紋

深入研究「Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics」主題。共同形成了獨特的指紋。

引用此