Dual-pathway multi-echo sequence for simultaneous frequency and T2 mapping

Cheng Chieh Cheng, Chang Sheng Mei, Jeffrey Duryea, Hsiao Wen Chung, Tzu Cheng Chao, Lawrence P. Panych, Bruno Madore

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)


Purpose: To present a dual-pathway multi-echo steady state sequence and reconstruction algorithm to capture T2, T2 and field map information. Methods: Typically, pulse sequences based on spin echoes are needed for T2 mapping while gradient echoes are needed for field mapping, making it difficult to jointly acquire both types of information. A dual-pathway multi-echo pulse sequence is employed here to generate T2 and field maps from the same acquired data. The approach might be used, for example, to obtain both thermometry and tissue damage information during thermal therapies, or susceptibility and T2 information from a same head scan, or to generate bonus T2 maps during a knee scan. Results: Quantitative T2, T2 and field maps were generated in gel phantoms, ex vivo bovine muscle, and twelve volunteers. T2 results were validated against a spin-echo reference standard: A linear regression based on ROI analysis in phantoms provided close agreement (slope/R2 = 0.99/0.998). A pixel-wise in vivo Bland–Altman analysis of R2 = 1/T2 showed a bias of 0.034 Hz (about 0.3%), as averaged over four volunteers. Ex vivo results, with and without motion, suggested that tissue damage detection based on T2 rather than temperature-dose measurements might prove more robust to motion. Conclusion: T2, T2 and field maps were obtained simultaneously, from the same datasets, in thermometry, susceptibility-weighted imaging and knee-imaging contexts.

頁(從 - 到)177-187
期刊Journal of Magnetic Resonance
出版狀態Published - 2016 4月 1

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物化學
  • 核能與高能物理
  • 凝聚態物理學


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