Dual-stimuli responsive polymeric micelles: preparation, characterization, and controlled drug release

Wen Chung Wu, Yu Sheng Kuo, Chung Hao Cheng

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

The preparation of stimuli-responsive polymeric micelles sensitive to both temperature and UV irradiation is achieved through the self-assembly from a series of amphiphilic block copolymers, poly(triethylene glycol methacrylate)-b-poly(2-nitrobenzyl methacrylate) (PTEGMA-b-PNBMA). The block ratios of the hydrophilic and thermo-responsive PTEGMA block to the hydrophobic and photoclevable PNBMA block are manipulated in the range of 4:1 to 1:1. The nanostructure and stimuli-responsive properties of the micelles are well-correlated with the chemical structures of the copolymers. The thermal transition temperature of micelles is reduced to 38–41 °C and close to body temperature as compared to that of PTEGMA homopolymer around 52 °C. After UV irradiation, the enhanced hydrophilicity of micelle core causes swelling and increased size of micelles. The capabilities of these micelles for drug encapsulation are demonstrated by using doxorubicin as the model drug and the subsequent drug release could be triggered by elevated temperature and/or UV irradiation. Furthermore, the potential application of these micelles in controlled drug release is explored by studying the in vitro cytotoxicity of drug-loaded micelles as triggered by external stimuli.

原文English
文章編號80
期刊Journal of Polymer Research
22
發行號5
DOIs
出版狀態Published - 2015 4月 16

All Science Journal Classification (ASJC) codes

  • 聚合物和塑料
  • 有機化學
  • 材料化學

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