Dynamics of dielectrophoretic field-flow fractionation (dep-fff) based micro sorter for cell separation

Tzong-Shyng Leu, Chih Yuan Weng

研究成果: Article

8 引文 (Scopus)

摘要

Dielectrophoretic Field-Flow Fractionation (DEP-FFF) is a technique that selects particles of interest from a mixture of many samples. Conventional DEP-FFF technique used DEP force to levitate particles to different heights according to their dielectric properties. Levitated particles are then separated by their velocity difference in a microchannel. Numerical simulation and experimental results found that particles become wavy trajectory when the ratio of levitation height (hp) and average of electrode width and spacing (d) is below 0.6 (hp/d<0.6). In the mean time, sorted particles disperse randomly in Y-direction, too. The wavy trajectory and random distribution cause cell separation imprecisely. A novel MEMS-fabricated DEP-FFF based micro sorters is designed to improve these problems. The experimental results show that the particles can be levitated to a constant height and focus into a single particle stream along the centerline in the new micro sorter design. One can conclude that the new design leads to better cell separation in a DEP-FFF based micro sorter.

原文English
頁(從 - 到)389-392
頁數4
期刊Modern Physics Letters B
23
發行號3
DOIs
出版狀態Published - 2009 一月 30

指紋

fractionation
flow distribution
cells
trajectories
levitation
microchannels
statistical distributions
microelectromechanical systems
dielectric properties
spacing
electrodes
causes
simulation

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics

引用此文

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