Dysfunction screening in experimental arteriovenous grafts for hemodialysis using inflow and outflow hemodynamic game analysis

Wei Ling Chen, Chung Dann Kan, Chia Hung Lin

研究成果: Conference contribution

摘要

Hemodialysis access stenosis leading to dysfunction occurs at the venous anastomsis site or the outflow vein. Information from the inflow stenosis, such as blood pressure, flow velocity, and flow resistance increases, allows dysfunction screening from early clots and thrombosis to the progress of outflow stenosis. To prevent access complications, such as inflow / outflow stenosis and steal syndrome, this study proposes the dysfunction screening in experimental arteriovenous grafts (AVGs) for hemodialysis using inflow and outflow hemodynamic game analysis. In physical examinations, a stenosis limits flow volume, and then the pressure at a stenotic locus rapidly falls between inflow and outflow. Therefore, pressure drop and flow resistance can be estimated based on variations in flow volume. The quantitative differences can be applied to evaluate the risk of access dysfunction, in terms of the degree of stenosis (DOS). With the differential pressure sensors, the measured pressure drop, AP, is used to estimate the injection velocity, Vinj, and resistance (Res) index through an experimental AVG. A cooperative game (CG) based decision-making model is then utilized to evaluate the risk of an AVG dysfunction. The proposed model is implemented with the LabVIEW graphical programming. For an equivalent human circulation system, a total of 72 measurements were made at each inflow and outflow site, at locations ± lDa, l = 5,10,17 and Da = 0.635cm. At least 6 measurements were made at each location under various DOS with varying 50% to 95%. The findings indicate that the proposed measurement method and decision-making model can be carried out in practical examinations during hemodialysis.

原文English
主出版物標題World Congress on Medical Physics and Biomedical Engineering, 2015
編輯David A. Jaffray
發行者Springer Verlag
頁面309-317
頁數9
ISBN(列印)9783319193878
DOIs
出版狀態Published - 2015 一月 1
事件World Congress on Medical Physics and Biomedical Engineering, 2015 - Toronto, Canada
持續時間: 2015 六月 72015 六月 12

出版系列

名字IFMBE Proceedings
51
ISSN(列印)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering, 2015
國家/地區Canada
城市Toronto
期間15-06-0715-06-12

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 生物醫學工程

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