@article{05ee02dc3110404c8bd10ad4d40d8770,
title = "Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer",
abstract = "Although early detection and treatment of prostate cancer (PCa) improves outcomes, many patients still die of metastatic PCa. Here, we report that metastatic PCa exhibits reduced levels of the microRNAsmiR-101 and miR-27a. These micro-RNAs (miRNAs) negatively regulate cell invasion and inhibit the expression of FOXM1 and CENPF, two master regulators of metastasis in PCa. Interestingly, the repression of FOXM1 and CENPF by these miRNAs occurs through COUP-TFII, a member of the orphan nuclear receptors family. Loss of miR-101 positively correlates with the increase of COUP-TFII-FOXM1-CENPF activity in clinical PCa data sets, implicating clinical relevance of such regulation. Further studies show that COUP-TFII is a critical factor controlling metastatic gene networks to promote PCa metastasis. Most importantly, this miRNA-COUP-TFII-FOXM1-CENPF regulatory axis is also involved in the development of enzalutaminde resistance. Taken together, our findings highlight the contribution of specific miRNAs through the regulation of the COUP-TFII-FOXM1-CENPF cascade in PCa metastasis and drug resistance.",
author = "Lin, {Shih Chieh} and Kao, {Chung Yang} and Lee, {Hui Ju} and Creighton, {Chad J.} and Ittmann, {Michael M.} and Tsai, {Shaw Jenq} and Tsai, {Sophia Y.} and Tsai, {Ming Jer}",
note = "Funding Information: We thank Ms Pei Li and Ms Guannu Xu in the Tsai laboratory, Ms Fengju Chen in the Creighton Laboratory and Ms Yi-Shang-Yeh and Ms Yi-Chen Tang in the SJ Tsai Laboratory for technical assistance. We also thank Ms Jodie Hebert for the manuscript preparation. Prostate cancer specimens were provided by the Pathological core of the Dan L. Duncan Cancer Center, Baylor College of Medicine (P30 DK079638 and P30 CA125123). We also thank the Bioinformatics Center of National Cheng Kung University for providing bioinformatic analytic tools (MetaCore). This work was supported by grants from NSC 102-2917-I-564-011 to S.-C.L., NSC102-2321-B-006-011 and D104-35B05 to S.-J.T., NIH DK59820 and HL114539 and CPRIT RP130315 to S.Y.T. and M.- J.T. We acknowledge the joint participation by Adrienne Helis Malvin Medical Research Foundation through its direct engagement in the continuous active conduct of medical research in conjunction with Baylor College of Medicine and its 'Role of nuclear receptor COUP-TFII in PCa growth and metastasis' Cancer Program.",
year = "2016",
month = apr,
day = "25",
doi = "10.1038/ncomms11418",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}