Early assessment of breast cancer response to neoadjuvant chemotherapy by semi-quantitative analysis of high-temporal resolution DCE-MRI: Preliminary results

Richard G. Abramson, Xia Li, Tamarya Lea Hoyt, Pei Fang Su, Lori R. Arlinghaus, Kevin J. Wilson, Vandana G. Abramson, A. Bapsi Chakravarthy, Thomas E. Yankeelov

研究成果: Article同行評審

61 引文 斯高帕斯(Scopus)

摘要

Purpose: To evaluate whether semi-quantitative analysis of high temporal resolution dynamic contrast-enhanced MRI (DCE-MRI) acquired early in treatment can predict the response of locally advanced breast cancer (LABC) to neoadjuvant chemotherapy (NAC). Materials and Methods: As part of an IRB-approved prospective study, 21 patients with LABC provided informed consent and underwent high temporal resolution 3. T DCE-MRI before and after 1. cycle of NAC. Using measurements performed by two radiologists, the following parameters were extracted for lesions at both examinations: lesion size (short and long axes, in both early and late phases of enhancement), radiologist's subjective assessment of lesion enhancement, and percentages of voxels within the lesion demonstrating progressive, plateau, or washout kinetics. The latter data were calculated using two filters, one selecting for voxels enhancing ≥. 50% over baseline and one for voxels enhancing ≥. 100% over baseline. Pretreatment imaging parameters and parameter changes following cycle 1 of NAC were evaluated for their ability to discriminate patients with an eventual pathological complete response (pCR). Results: All 21 patients completed NAC followed by surgery, with 9 patients achieving a pCR. No pretreatment imaging parameters were predictive of pCR. However, change after cycle 1 of NAC in percentage of voxels demonstrating washout kinetics with a 100% enhancement filter discriminated patients with an eventual pCR with an area under the receiver operating characteristic curve (AUC) of 0.77. Changes in other parameters, including lesion size, did not predict pCR. Conclusion: Semi-quantitative analysis of high temporal resolution DCE-MRI in patients with LABC can discriminate patients with an eventual pCR after one cycle of NAC.

原文English
頁(從 - 到)1457-1464
頁數8
期刊Magnetic Resonance Imaging
31
發行號9
DOIs
出版狀態Published - 2013 11月

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物醫學工程
  • 放射學、核子醫學和影像學

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