Early experimental results of colorectal carcinoma chemotherapeutics by liposomal curcuminoids

Ming Jenn Chen, Yu Wen Lin, Ya Min Cheng, June Fu Wu, Yi Chiang Hsu

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Curcuminoids had shown anti-proliferation and induce the apoptosis in many cancer cells. It was chosen as the model drug and liposome, a biocompatible and biodegradable carrier was used (liposomal curcuminoids; LPC). The technique was also investigated for the possibility of facilitating the anti-tumor activity of LPC in colorectal cancer (CRC). In-vitro permeation studies in fresh pig colon mucosa; we found that reduced the cumulative amount and flux of LPC. There are 7.8 folds decreasing which compared to the curcuminoids treatment without liposomal encapsulation. Summary the results show that the liposomal encapsulation could enhance and prolong the cytotoxicity of curcuminoids through possibly increase the cellular uptake of curcuminoids in colorectal cancer cell (CRC) lines (CP1 to CP5). Through the use of LPC, the transmucosa drug delivery system (DDS) of liposome encapsulation to the CRC cancer therapy could be made possible.

原文English
頁(從 - 到)1445-1456
頁數12
期刊Digest Journal of Nanomaterials and Biostructures
6
發行號3
出版狀態Published - 2011

All Science Journal Classification (ASJC) codes

  • 結構生物學
  • 原子與分子物理與光學
  • 生物醫學工程
  • 一般材料科學
  • 凝聚態物理學
  • 物理與理論化學

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