Early intervention with high-dose steroid pulse therapy prolongs disease-free interval of severe alopecia areata: A retrospective study

Chao Chun Yang, Chun Te Lee, Chao Kai Hsu, Yi Pei Lee, Tak Wah Wong, Sheau Chiou Chao, Julia Yu Yun Lee, Hamm Ming Sheu, Wen Chieh Chen

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

Background: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. Objective: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Department of Dermatology, National Cheng Kung University Hospital. Methods: Data were retrospectively retrieved. A satisfactory response was defined as more than 75% hair regrowth in the balding area. Results: A total of 85 patients with more than 50% hair loss were identified and treated, with an overall satisfactory response rate of 51.8%. The mean follow-up time was 37.6 months, with a relapse rate of 22.7%. Patients with alopecia areata (hereafter, AA) of recent onset within one year showed higher response rates (p<0.001) and lower relapse rates compared to patients with AA persisting for more than 1 year. Further, even in patients with alopecia totalis, alopecia universalis or ophiasis type, early treatment resulted in a satisfactory response rate of 47% among the treated patients. In general, oral therapy was as effective and well-tolerated as intravenous therapy. Conclusion: The response rate is determined by disease severity and time of intervention, not by the administration form of steroid pulse therapy. Oral steroid pulse therapy can be considered as the first-line treatment for patients with severe AA of recent onset within one year. (Ann Dermatol 25(4) 471~474, 2013).

原文English
頁(從 - 到)471-474
頁數4
期刊Annals of Dermatology
25
發行號4
DOIs
出版狀態Published - 2013 11月

All Science Journal Classification (ASJC) codes

  • 皮膚科

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