EBV viral load in tumor tissue is an important prognostic indicator for nasal NK/T-cell lymphoma

Pin Pen Hsieh, Chun Liang Tung, Amy Bik Wan Chan, Jia Bin Liao, Jyh Seng Wang, Hui Hwa Tseng, Hsing Hao Su, Kun Chao Chang, Chung Che Chang

研究成果: Article同行評審

32 引文 斯高帕斯(Scopus)

摘要

We retrospectively studied 19 cases of nasal NK/T-cell lymphoma for various potential prognostic factors and performed real-time quantitative polymerase chain reaction for Epstein-Barr virus (EBV) viral load in tumor tissue. Patients with a low EBV viral load (<1 copy per cell) more frequently survived for more than 2 years compared with patients with a high EBV viral load (≥1 copies/cell) (7/7 vs 3/9; P = .014; Fisher exact test). Furthermore, the patients with low EBV viral loads had a better overall survival than patients with high viral loads (50% accumulative survival: not reached vs 4-5 months; Kaplan-Meier survival analysis; P = .049). In contrast, the overall survival of the patients did not correlate with the extent of lesion, age, stage, necrosis, histologic subtypes, CD56 expression, or angiocentric or angiodestructive growth pattern. Our findings suggest that the EBV viral load in tumor tissues is a useful indicator for predicting outcome of nasal NK/T-cell lymphoma.

原文English
頁(從 - 到)579-584
頁數6
期刊American Journal of Clinical Pathology
128
發行號4
DOIs
出版狀態Published - 2007 十月

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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