Educational level influences regional cerebral blood flow in patients with Alzheimer's disease

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

We tested the hypothesis that educational level influences regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients. Methods: The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using 99mTc- hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educational levels were determined using statistical parametric mapping (SPM). Results: In matched low-education (≤6 y; n = 29) and high-education (>6 y; n = 29) groups, SPM revealed 2 statistically significant clusters of voxels with higher rCBF in the high-education group: one in the left lateral inferior, middle, and superior temporal gyrus; another in the left medial temporal area to the left inferior frontal gyrus. Conclusion: We provide biologic evidence that education may lead to relatively higher rCBF in specific areas in AD patients, which may explain the effects of education on clinical manifestations of AD.

原文English
頁(從 - 到)1860-1863
頁數4
期刊Journal of Nuclear Medicine
45
發行號11
出版狀態Published - 2004 11月 1

All Science Journal Classification (ASJC) codes

  • 放射學、核子醫學和影像學

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