Effect of dopamine on immune cell proliferation in mice

Chiung Wen Tsao, Yee Shin Lin, Juei Tang Cheng

研究成果: Article同行評審

52 引文 斯高帕斯(Scopus)


Dopamine is known as a precursor of catecholamine and one of the neurotransmitters in brain and peripheral tissues. Recent studies suggest an important role of dopamine in immune responses. In the present study, intraperitoneal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which lowered endogenous dopamine suppressed splenocyte proliferation in response to mitogens such as lipopolysaccharide (LPS) and concanavalin A (Con A). Moreover, intravenous injection of the specific agonists of dopamine DA-1 receptor (SKF38393) or DA-2 receptor (LY171555) into mice enhanced the splenocyte proliferation stimulated by LPS or Con A. In the in vitro cultures, dopamine, SKF38393 and LY171555 directly promoted cell proliferation to LPS or Con A. These results indicate that dopamine has an ability to regulate B- and T-cell proliferation both in vivo and in vitro.

頁(從 - 到)PL361-PL371
期刊Life Sciences
出版狀態Published - 1997 11月 4

All Science Journal Classification (ASJC) codes

  • 一般藥理學、毒理學和製藥學
  • 一般生物化學,遺傳學和分子生物學


深入研究「Effect of dopamine on immune cell proliferation in mice」主題。共同形成了獨特的指紋。