Effect of Lavender essential oil on LPS-stimulated inflammation

Mei Yu Huang, May Hua Liao, Yang Kao Wang, Yung Sheng Huang, Hsiao Chuan Wen

研究成果: Article

21 引文 (Scopus)

摘要

Lavender essential oil (LEO) is one the most favorite and widely used essential oils in aromatherapy. Many studies have demonstrated its functions in calming, assisting sleep, reducing pain and muscular spasms and its antiseptic function. To date, however, the mechanism of LEO on inflammation response is not well understood. In this study, we examined the effect of LEO on 5 μg/ml lipopolysaccharide (LPS) induced inflammation reaction in human monocyte THP-1 cells. We found treatment of 0.1% LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells. Treatment with LEO down-regulated both LPS-induced protein levels of phospho-NF-κB and membrane Toll-llike receptor 4. To determine whether the chaperone protein was involved in the reaction, we determined the levels of Heat Shock Protein 70 (HSP70). Our results showed that LEO increased HSP70 expression in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited LPS-induced inflammatory effect might be associated with the expression of HSP70.

原文English
頁(從 - 到)845-859
頁數15
期刊American Journal of Chinese Medicine
40
發行號4
DOIs
出版狀態Published - 2012 七月 30

指紋

Volatile Oils
Lipopolysaccharides
Inflammation
HSP70 Heat-Shock Proteins
Aromatherapy
Toll-Like Receptor 4
Local Anti-Infective Agents
lavender oil
Spasm
Interleukin-1
Superoxides
Monocytes
Cell Survival
Sleep
Proteins
Pain
Membranes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

引用此文

Huang, Mei Yu ; Liao, May Hua ; Wang, Yang Kao ; Huang, Yung Sheng ; Wen, Hsiao Chuan. / Effect of Lavender essential oil on LPS-stimulated inflammation. 於: American Journal of Chinese Medicine. 2012 ; 卷 40, 編號 4. 頁 845-859.
@article{9d60b507938046afbaf68d157b61587b,
title = "Effect of Lavender essential oil on LPS-stimulated inflammation",
abstract = "Lavender essential oil (LEO) is one the most favorite and widely used essential oils in aromatherapy. Many studies have demonstrated its functions in calming, assisting sleep, reducing pain and muscular spasms and its antiseptic function. To date, however, the mechanism of LEO on inflammation response is not well understood. In this study, we examined the effect of LEO on 5 μg/ml lipopolysaccharide (LPS) induced inflammation reaction in human monocyte THP-1 cells. We found treatment of 0.1{\%} LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells. Treatment with LEO down-regulated both LPS-induced protein levels of phospho-NF-κB and membrane Toll-llike receptor 4. To determine whether the chaperone protein was involved in the reaction, we determined the levels of Heat Shock Protein 70 (HSP70). Our results showed that LEO increased HSP70 expression in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited LPS-induced inflammatory effect might be associated with the expression of HSP70.",
author = "Huang, {Mei Yu} and Liao, {May Hua} and Wang, {Yang Kao} and Huang, {Yung Sheng} and Wen, {Hsiao Chuan}",
year = "2012",
month = "7",
day = "30",
doi = "10.1142/S0192415X12500632",
language = "English",
volume = "40",
pages = "845--859",
journal = "American Journal of Chinese Medicine",
issn = "0192-415X",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "4",

}

Effect of Lavender essential oil on LPS-stimulated inflammation. / Huang, Mei Yu; Liao, May Hua; Wang, Yang Kao; Huang, Yung Sheng; Wen, Hsiao Chuan.

於: American Journal of Chinese Medicine, 卷 40, 編號 4, 30.07.2012, p. 845-859.

研究成果: Article

TY - JOUR

T1 - Effect of Lavender essential oil on LPS-stimulated inflammation

AU - Huang, Mei Yu

AU - Liao, May Hua

AU - Wang, Yang Kao

AU - Huang, Yung Sheng

AU - Wen, Hsiao Chuan

PY - 2012/7/30

Y1 - 2012/7/30

N2 - Lavender essential oil (LEO) is one the most favorite and widely used essential oils in aromatherapy. Many studies have demonstrated its functions in calming, assisting sleep, reducing pain and muscular spasms and its antiseptic function. To date, however, the mechanism of LEO on inflammation response is not well understood. In this study, we examined the effect of LEO on 5 μg/ml lipopolysaccharide (LPS) induced inflammation reaction in human monocyte THP-1 cells. We found treatment of 0.1% LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells. Treatment with LEO down-regulated both LPS-induced protein levels of phospho-NF-κB and membrane Toll-llike receptor 4. To determine whether the chaperone protein was involved in the reaction, we determined the levels of Heat Shock Protein 70 (HSP70). Our results showed that LEO increased HSP70 expression in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited LPS-induced inflammatory effect might be associated with the expression of HSP70.

AB - Lavender essential oil (LEO) is one the most favorite and widely used essential oils in aromatherapy. Many studies have demonstrated its functions in calming, assisting sleep, reducing pain and muscular spasms and its antiseptic function. To date, however, the mechanism of LEO on inflammation response is not well understood. In this study, we examined the effect of LEO on 5 μg/ml lipopolysaccharide (LPS) induced inflammation reaction in human monocyte THP-1 cells. We found treatment of 0.1% LEO significantly increased cell viability and inhibited the IL-1β and superoxide anion generation in LPS-stimulated THP-1 cells. Treatment with LEO down-regulated both LPS-induced protein levels of phospho-NF-κB and membrane Toll-llike receptor 4. To determine whether the chaperone protein was involved in the reaction, we determined the levels of Heat Shock Protein 70 (HSP70). Our results showed that LEO increased HSP70 expression in LPS-stimulated THP-1 cells, suggesting that the LEO inhibited LPS-induced inflammatory effect might be associated with the expression of HSP70.

UR - http://www.scopus.com/inward/record.url?scp=84864234119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864234119&partnerID=8YFLogxK

U2 - 10.1142/S0192415X12500632

DO - 10.1142/S0192415X12500632

M3 - Article

C2 - 22809036

AN - SCOPUS:84864234119

VL - 40

SP - 845

EP - 859

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

SN - 0192-415X

IS - 4

ER -