Effect of N-(biphenylyl-methyl)imidazole, a type 1 angiotensin II receptor inhibitor, on the contractile function of the rat corpus cavernosum

Yat-Ching Tong, Chia Jane Wang, Paul Chan, Juei Tang Cheng

研究成果: Article

摘要

The effect of N-(biphenylyl-methyl)imidazole, losartan potassium, a newly developed antihypertensive type 1 angiotensin II receptor antagonist on the rat erectile function, was studied. Sexually active 9-week-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were given losartan 60 mg/kg intraperitoneal injections. Mean blood pressure (MBP) dropped significantly in both SHR and WKY rats (for SHR: from 140 ± 8 to 114 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 113 ± 7 to 79 ± 9 mm Hg, p < 0.05, n = 8). On the contrary, the intracavernous pressure (ICP) of SHR and WKY rats did not differ significantly from that of the corresponding controls receiving saline injections (p > 0.05, n = 8 for each group). For the chronic study, the rats were fed with losartan 30 mg/kg/day for 30 days. MBP decreased significantly in SHR but not in WKY rats (for SHR: from 137 ± 7 to 113 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 110 ± 6 to 107 ± 5 mm Hg, p > 0.05, n = 8). The ICP of the losartan-treated rats was not significantly different from that of control rats (p > 0.05, n = 8 for each group). In contrast, WKY rats receiving guanethidine 1 mg/kg/day for 30 days showed significantly decreased ICP. Angiotensin II (10-9-10-5 M) and losartan (10-9-10-5 M) did not induce significant contractile responses of the cavernosal strip when tested in vitro. On the other hand, methoxamine 10-4 M induced good contractile responses. In conclusion, the present study demonstrated that angiotensin II did not cause significant change in the contractile status of rat corpus cavernosum. Correspondingly, the type 1 angiotensin II inhibitor effectively lowered blood pressure but did not affect cavernosal contractile function, thus is useful clinically in the treatment of hypertensive disorders without significant detrimental effects on male sexual function. Copyrit (C) 2000 S. Karger G, Basel.

原文English
頁(從 - 到)149-153
頁數5
期刊Urologia Internationalis
64
發行號3
DOIs
出版狀態Published - 2000 一月 1

指紋

Angiotensin Type 1 Receptor
Losartan
Inbred SHR Rats
Inbred WKY Rats
Angiotensin II
Blood Pressure
Methoxamine
Angiotensin II Type 1 Receptor Blockers
Guanethidine
Intraperitoneal Injections
Antihypertensive Agents
imidazole

All Science Journal Classification (ASJC) codes

  • Urology

引用此文

@article{c3b8b8ad43af4dcf9c2ff0900b65c759,
title = "Effect of N-(biphenylyl-methyl)imidazole, a type 1 angiotensin II receptor inhibitor, on the contractile function of the rat corpus cavernosum",
abstract = "The effect of N-(biphenylyl-methyl)imidazole, losartan potassium, a newly developed antihypertensive type 1 angiotensin II receptor antagonist on the rat erectile function, was studied. Sexually active 9-week-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were given losartan 60 mg/kg intraperitoneal injections. Mean blood pressure (MBP) dropped significantly in both SHR and WKY rats (for SHR: from 140 ± 8 to 114 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 113 ± 7 to 79 ± 9 mm Hg, p < 0.05, n = 8). On the contrary, the intracavernous pressure (ICP) of SHR and WKY rats did not differ significantly from that of the corresponding controls receiving saline injections (p > 0.05, n = 8 for each group). For the chronic study, the rats were fed with losartan 30 mg/kg/day for 30 days. MBP decreased significantly in SHR but not in WKY rats (for SHR: from 137 ± 7 to 113 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 110 ± 6 to 107 ± 5 mm Hg, p > 0.05, n = 8). The ICP of the losartan-treated rats was not significantly different from that of control rats (p > 0.05, n = 8 for each group). In contrast, WKY rats receiving guanethidine 1 mg/kg/day for 30 days showed significantly decreased ICP. Angiotensin II (10-9-10-5 M) and losartan (10-9-10-5 M) did not induce significant contractile responses of the cavernosal strip when tested in vitro. On the other hand, methoxamine 10-4 M induced good contractile responses. In conclusion, the present study demonstrated that angiotensin II did not cause significant change in the contractile status of rat corpus cavernosum. Correspondingly, the type 1 angiotensin II inhibitor effectively lowered blood pressure but did not affect cavernosal contractile function, thus is useful clinically in the treatment of hypertensive disorders without significant detrimental effects on male sexual function. Copyrit (C) 2000 S. Karger G, Basel.",
author = "Yat-Ching Tong and Wang, {Chia Jane} and Paul Chan and Cheng, {Juei Tang}",
year = "2000",
month = "1",
day = "1",
doi = "10.1159/000030516",
language = "English",
volume = "64",
pages = "149--153",
journal = "Urologia Internationalis",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Effect of N-(biphenylyl-methyl)imidazole, a type 1 angiotensin II receptor inhibitor, on the contractile function of the rat corpus cavernosum

AU - Tong, Yat-Ching

AU - Wang, Chia Jane

AU - Chan, Paul

AU - Cheng, Juei Tang

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The effect of N-(biphenylyl-methyl)imidazole, losartan potassium, a newly developed antihypertensive type 1 angiotensin II receptor antagonist on the rat erectile function, was studied. Sexually active 9-week-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were given losartan 60 mg/kg intraperitoneal injections. Mean blood pressure (MBP) dropped significantly in both SHR and WKY rats (for SHR: from 140 ± 8 to 114 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 113 ± 7 to 79 ± 9 mm Hg, p < 0.05, n = 8). On the contrary, the intracavernous pressure (ICP) of SHR and WKY rats did not differ significantly from that of the corresponding controls receiving saline injections (p > 0.05, n = 8 for each group). For the chronic study, the rats were fed with losartan 30 mg/kg/day for 30 days. MBP decreased significantly in SHR but not in WKY rats (for SHR: from 137 ± 7 to 113 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 110 ± 6 to 107 ± 5 mm Hg, p > 0.05, n = 8). The ICP of the losartan-treated rats was not significantly different from that of control rats (p > 0.05, n = 8 for each group). In contrast, WKY rats receiving guanethidine 1 mg/kg/day for 30 days showed significantly decreased ICP. Angiotensin II (10-9-10-5 M) and losartan (10-9-10-5 M) did not induce significant contractile responses of the cavernosal strip when tested in vitro. On the other hand, methoxamine 10-4 M induced good contractile responses. In conclusion, the present study demonstrated that angiotensin II did not cause significant change in the contractile status of rat corpus cavernosum. Correspondingly, the type 1 angiotensin II inhibitor effectively lowered blood pressure but did not affect cavernosal contractile function, thus is useful clinically in the treatment of hypertensive disorders without significant detrimental effects on male sexual function. Copyrit (C) 2000 S. Karger G, Basel.

AB - The effect of N-(biphenylyl-methyl)imidazole, losartan potassium, a newly developed antihypertensive type 1 angiotensin II receptor antagonist on the rat erectile function, was studied. Sexually active 9-week-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were given losartan 60 mg/kg intraperitoneal injections. Mean blood pressure (MBP) dropped significantly in both SHR and WKY rats (for SHR: from 140 ± 8 to 114 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 113 ± 7 to 79 ± 9 mm Hg, p < 0.05, n = 8). On the contrary, the intracavernous pressure (ICP) of SHR and WKY rats did not differ significantly from that of the corresponding controls receiving saline injections (p > 0.05, n = 8 for each group). For the chronic study, the rats were fed with losartan 30 mg/kg/day for 30 days. MBP decreased significantly in SHR but not in WKY rats (for SHR: from 137 ± 7 to 113 ± 5 mm Hg, p < 0.05, n = 8; for WKY: from 110 ± 6 to 107 ± 5 mm Hg, p > 0.05, n = 8). The ICP of the losartan-treated rats was not significantly different from that of control rats (p > 0.05, n = 8 for each group). In contrast, WKY rats receiving guanethidine 1 mg/kg/day for 30 days showed significantly decreased ICP. Angiotensin II (10-9-10-5 M) and losartan (10-9-10-5 M) did not induce significant contractile responses of the cavernosal strip when tested in vitro. On the other hand, methoxamine 10-4 M induced good contractile responses. In conclusion, the present study demonstrated that angiotensin II did not cause significant change in the contractile status of rat corpus cavernosum. Correspondingly, the type 1 angiotensin II inhibitor effectively lowered blood pressure but did not affect cavernosal contractile function, thus is useful clinically in the treatment of hypertensive disorders without significant detrimental effects on male sexual function. Copyrit (C) 2000 S. Karger G, Basel.

UR - http://www.scopus.com/inward/record.url?scp=0034083936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034083936&partnerID=8YFLogxK

U2 - 10.1159/000030516

DO - 10.1159/000030516

M3 - Article

C2 - 10859546

AN - SCOPUS:0034083936

VL - 64

SP - 149

EP - 153

JO - Urologia Internationalis

JF - Urologia Internationalis

SN - 0042-1138

IS - 3

ER -