Effect of polysaccharide derived from dehulled adlay on regulating gut microbiota and inhibiting Clostridioides difficile in an in vitro colonic fermentation model

Bao Hong Lee, Shih Ching Huang, Chih Yao Hou, You Zuo Chen, Yu Hsin Chen, Sulfath Hakkim Hazeena, Wei Hsuan Hsu

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

Human body can digest only a few sugars with a low degree of polymerization. The rest of the carbohydrates become food for gastrointestinal symbiotic bacteria, affecting gut microbiota composition and human health. Adlay is a medicinal and food homologous crop. The study aims to determine whether dehulled adlay-derived polysaccharide regulates gut microbiota and barrier function to against Clostridioides difficile infection. Major molecular weight of adlay polysaccharide is 27 kDa. The growth of next-generation probiotics were promoted by adlay polysaccharides. In colonic fermentation model, the ratio of C. difficile was decreased when adding the condition medium of adlay polysaccharides-treated fecal microbiota. In addition, adlay polysaccharide promoted the expression of tight junction proteins and mucin in intestinal cells. This study shows that adlay polysaccharide can be used as prebiotics to regulate microbiota and maintain barrier function, which has the potential to be developed as novel functional food ingredients to protect intestinal health.

原文English
文章編號135410
期刊Food Chemistry
410
DOIs
出版狀態Published - 2023 6月 1

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 食品科學

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