Effect of Reducing Heart Rate on Outcomes in Patients With Reduced Ejection Fraction

Wei Ren Lan, Shu I. Lin, Feng Ching Liao, Hung Yu Chang, Cheng Ting Tsai, Yih Jer Wu, Ping Yen Liu, Chen Huan Chen, Ying Hsiang Lee

研究成果: Review article同行評審

3 引文 斯高帕斯(Scopus)


Since 1953, sinus tachycardia has been defined as a heart rate (HR) in sinus rhythm of >100 beats per minute (bpm). However, this number has never been formally evaluated, and no established threshold values for special groups, such as those with heart failure (HF) accompanied by a reduced ejection fraction (HFrEF). Herein, we provided evidence that lowering the HR of patients with HFrEF to <70 bpm with medications such as ivabradine improves outcomes. Numerous large-scale trials and smaller clinical studies have shown that reducing the HR in patients with HFrEF improves cardiovascular and overall outcomes. Evidence suggests that a HR of <70 bpm is appropriate for patients with HFrEF. Examination of HF registries indicates that in a large proportion of these patients the HR exceeds 80 bpm, and no consideration is given to lowering the HR, due in large part to lack of physician awareness of the benefits of a lower HR. Evidence indicates that the first-line medication for lowering HR in patients with HFrEF is ivabradine. In conclusion, the improved prognosis following appropriate HR management in patients with HFrEF suggest that the cut-off value for sinus tachycardia in these patients should be redefined as 75 bpm. Maintaining a HR of <70 bpm in patients with HFrEF is associated with improved cardiovascular and overall outcomes.

頁(從 - 到)77-81
期刊American Journal of Cardiology
出版狀態Published - 2021 7月 1

All Science Journal Classification (ASJC) codes

  • 心臟病學與心血管醫學


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