Effect of tethered sheet-like motif and asymmetric topology on hydrogelation of star-shaped block copolypeptides

Ching Chia Huang, Thi Ha My Phan, Tooru Ooya, Shiho Kawasaki, Bi Yun Lin, Jeng Shiung Jan

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

To study the hydrogelation and self-assembly ability of the star-shaped diblock copolypeptides, 6-armed and 12-armed block copolypeptides comprised of poly-L-Lysine (PLL) as the first block and separately tethered with different hydrophobic, sheet-like oligopeptides (β-motifs) were synthesized using polyglycerol dendritic initiators. The hydrogelation of these samples was driven by the various interactions and amphiphilic balances in the polypeptide assemblies, showing a strong dependence on arm number and β-motif. The incorporation of β-motifs could facilitate hydrogelation and the hydrogel mechanical properties could be tuned by varying the tethered β-motif. Moreover, the star-shaped block copolypeptides with a symmetric topology demonstrated a better hydrogelation ability than those asymmetric counterparts possibly due to their more efficient packing. The tethered β-motif strongly influenced both the molecular assembly and micro-/macroscopic structures. This study illustrated the tunability of polypeptide hydrogels by varying the arm number and tethered β-motif as well as the polypeptide chain symmetry.

原文English
文章編號124864
期刊polymer
250
DOIs
出版狀態Published - 2022 5月 26

All Science Journal Classification (ASJC) codes

  • 有機化學
  • 聚合物和塑料
  • 材料化學

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