Effects of Antiepileptic Drugs on Sperm Motility of Normal Controls and Epileptic Patients with Long‐Term Therapy

Shun‐Sheng ‐S Chen, Meng‐Ru ‐R Shen, Tsan‐Ju ‐J Chen, Shung‐Long ‐L Lai

研究成果: Article同行評審

59 引文 斯高帕斯(Scopus)

摘要

Summary: The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2‐h preincubation at 37°C. Both in vitro and in vivo studies demonstrated that AEDs inhibited sperm motility. When the drug effect was evaluated after the semen‐AED mixture had been preincubated for 2 h, sperm motility was inhibited to 50% of control at concentrations of 1.59,4.23, and 5.00 mM for phenytoin, carbamazepine, and valproate, respectively. Both with and without preincubation, phenobarbital, even up to 12.92 mM, did not inhibit the motility to <50% of the control. In the in vivo study, poor sperm motility was noted in epileptic patients with long‐term AED therapy despite serum levels within the therapeutic range. Shorter duration of activity of spermatozoa was also observated in these patients. Interference with sperm membrane function by AEDs may be the underlying mechanism.

原文English
頁(從 - 到)149-153
頁數5
期刊Epilepsia
33
發行號1
DOIs
出版狀態Published - 1992 一月

All Science Journal Classification (ASJC) codes

  • 神經內科
  • 神經病學(臨床)

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