Effects of blue-light-induced free radical formation from catechin hydrate on the inactivation of acinetobacter baumannii, including a carbapenem-resistant strain

Meei Ju Yang, Yi An Hung, Tak Wah Wong, Nan Yao Lee, Jeu Ming P. Yuann, Shiuh Tsuen Huang, Chun Yi Wu, Iou Zen Chen, Ji Yuan Liang

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

Catechin is a flavan-3-ol, a derivative of flavans, with four phenolic hydroxyl groups, which exhibits a wide range of physiological properties. Chromatographic analyses were employed to examine the effects of blue light irradiation on the changes of catechin hydrate in an alkaline condition. In particular, the detection of a superoxide anion radical (O2), a reactive oxygen species (ROS), and the inactivation of Acinetobacter baumannii (A. baumannii)—including a carbapenem-resistant A. baumannii (CRAB)—was investigated during the photoreaction of catechin hydrate. Following basification with blue light irradiation, the transparent solution of catechin hydrate turned yellowish, and a chromogenic catechin dimer was separated and identified as a proanthocyanidin. Adding ascorbic acid during the photolytic treatment of catechin hydrate decreased the dimer formation, suggesting that ascorbic acid can suppress the photosensitive oxidation of catechin. When catechin hydrate was irradiated by blue light in an alkaline solution, O2 was produced via photosensitized oxidation, enhancing the inactivation of A. baumannii and CRAB. The present findings on the photon-induced oxidation of catechin hydrate provides a safe practice for the inactivation of environmental microorganisms.

原文English
文章編號1631
期刊Molecules
23
發行號7
DOIs
出版狀態Published - 2018

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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