Effects of childhood adversity and its interaction with the maoa, bdnf, and comt polymorphisms on subclinical attention deficit/hyperactivity symptoms in generally healthy youth

Meng Che Tsai, Kai Jyun Jhang, Chih Ting Lee, Yu Fang Lin, Carol Strong, Yi Ching Lin, Yi Ping Hsieh, Chung Ying Lin

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

We aimed to investigate the effects of childhood adversity and its interaction with the polymorphisms in the monoamine oxidase A (MAOA), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) genes on attention and hyperactivity disorder (ADHD) symptoms in a community sample of generally healthy youth. Participants (N = 432) completed questionnaires assessing ADHD symptoms (i.e., inattention, hyperactivity, and impulsiveness) and adverse childhood experiences, such as adverse environments (AEs) and childhood maltreatment (CM). Salivary genomic DNA was used to test polymorphisms in MAOA, BDNF, and COMT genes. A gene score (GS) was created based on the number of risk allele in the studied genes. Multiple linear regressions were used to examine the genetic and environmental effects on ADHD symptoms. The univariate analysis indicated that CM was significantly associated with inattention (β = 0.48 [95% confidence interval 0.16–0.79]), hyperactivity (0.25 [0.06–0.45]), and impulsiveness (1.16 [0.26–2.05]), while the GS was associated with hyperactivity (0.22 [0.11–0.33]) and impulsiveness (0.56 [0.06–1.05]). Only the GS remained significantly associated with hyperactivity (0.25 [0.12–0.37]) and impulsiveness (0.79 [0.20–1.38]) when the gene-environment interaction term was added in the model. No effects were found for AE and the gene-environment interaction term. In conclusion, CM was associated with ADHD symptoms in emerging adulthood. Genetic factors may also play a significant role in the association with these outcomes.

原文English
文章編號122
期刊Children
7
發行號9
DOIs
出版狀態Published - 2020 9月

All Science Journal Classification (ASJC) codes

  • 兒科、圍產兒和兒童健康

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