Effects of increased systemic inflammation and central obesity on arterial stiffness in patients with nonalcoholic fatty liver disease

Ju Yi Chen, Chang Hua Chou, Wei Chuan Tsai, Ming Cheng Wang, Chin Shan Ho, Yi Heng Li, Yau Sheng Tsai, Liang Miin Tsai

研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)

摘要

Nonalcoholic fatty liver disease (NAFLD) is associated with increasing arterial stiffness. We studied the effects of inflammation on different measurements of arterial stiffness in NAFLD. We recruited 80 patients with NAFLD and 40 control subjects. Both compliance index (CI) and stiffness index (SI) were measured. Patients with NAFLD had significantly lower CI (3.8 ± 2.1 vs 4.9 ± 2.9 units; P <.05) and higher SI (8.5 ± 2.4 vs 7.1 ± 1.5 m/s; P <.05) than the controls. Patients with NAFLD were further divided into 2 groups according to the median level of high-sensitivity C-reactive protein (hs-CRP). The CI was significantly lower in patients with NAFLD with high hs-CRP than in those with low hs-CRP (3.2 ± 1.7 vs 4.4 ± 2.5 units; P <.05); however, SI was not statistically different. We further found that waist circumference (odds ratio, 1.06; 95% confidence interval, 1.01-1.13; P <.05) was the only independent factor that predicted low CI (<median value) in patients with NAFLD. Central obesity was an important determinant both for increased arterial stiffness and hs-CRP in Patients with NAFLD.

原文English
頁(從 - 到)253-260
頁數8
期刊Journal of the American Society of Hypertension
6
發行號4
DOIs
出版狀態Published - 2012 七月

All Science Journal Classification (ASJC) codes

  • 內科學
  • 心臟病學與心血管醫學

指紋

深入研究「Effects of increased systemic inflammation and central obesity on arterial stiffness in patients with nonalcoholic fatty liver disease」主題。共同形成了獨特的指紋。

引用此