Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

Hui Ching Lin, Sheng Chun Mao, Po Wu Gean

研究成果: Article同行評審

92 引文 斯高帕斯(Scopus)

摘要

The cannabinoid CB1 receptor has been shown to be critically involved in the extinction of fear memory. Systemic injection of a CB1 receptor antagonist prior to extinction training blocked extinction. Conversely, administration of the cannabinoid uptake inhibitor AM404 facilitated extinction in a dose-dependent manner. Here we show that bilateral infusion of CB1 receptor agonists into the amygdala after memory reactivation blocked reconsolidation of fear memory measured with fear-potentiated startle. The effect was dose-dependent and could be blocked by AM251, a specific CB1 receptor antagonist. In contrast, the effect of CB1 agonists on reconsolidation was no longer seen if memory reactivation was omitted. Concomitant with block of reconsolidation, CB1 agonist-treated animals did not exhibit shock-induced reinstatement or spontaneous recovery of fear. The absence of recovery was not attributable to permanent damage to the amygdala in WIN-treated rats, nor did the effect result from alteration of baseline startle or shock reactivity. These results suggest that CB1 agonists could impair fear memory via blocking reconsolidation.

原文English
頁(從 - 到)316-321
頁數6
期刊Learning and Memory
13
發行號3
DOIs
出版狀態Published - 2006 五月

All Science Journal Classification (ASJC) codes

  • 神經心理學與生理心理學
  • 認知神經科學
  • 細胞與分子神經科學

指紋

深入研究「Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle」主題。共同形成了獨特的指紋。

引用此