Effects of lipids and lipoproteins on mesenchymal stem cells used in cardiac tissue regeneration

Yi Hsiung Lin, Lin Kang, Wen Han Feng, Tsung Lin Cheng, Wei Chung Tsai, Hsuan Ti Huang, Hsiang Chun Lee, Chung Hwan Chen

研究成果: Review article

摘要

Mesenchymal stem cells (MSCs) have two characteristics of interest for this paper: the ability to self-renew, and the potential for multiple-lineage differentiation into various cells. MSCs have been used in cardiac tissue regeneration for over a decade. Adult cardiac tissue regeneration ability is quite low; it cannot repair itself after injury, as the heart cells are replaced by fibroblasts and lose function. It is therefore important to search for a feasible way to repair and restore heart function through stem cell therapy. Stem cells can differentiate and provide a source of progenitor cells for cardiomyocytes, endothelial cells, and supporting cells. Studies have shown that the concentrations of blood lipids and lipoproteins affect cardiovascular diseases, such as atherosclerosis, hypertension, and obesity. Furthermore, the MSC lipid profiles, such as the triglyceride and cholesterol content, have been revealed by lipidomics, as well as their correlation with MSC differentiation. Abnormal blood lipids can cause serious damage to internal organs, especially heart tissue. In the past decade, the accumulated literature has indicated that lipids/lipoproteins affect stem cell behavior and biological functions, including their multiple lineage capability, and in turn affect the outcome of regenerative medicine. This review will focus on the effect of lipids/lipoproteins on MSC cardiac regenerative medicine, as well as the effect of lipid-lowering drugs in promoting cardiomyogenesis-associated MSC differentiation.

原文English
文章編號4770
頁(從 - 到)1-17
頁數17
期刊International journal of molecular sciences
21
發行號13
DOIs
出版狀態Published - 2020 七月 1

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

指紋 深入研究「Effects of lipids and lipoproteins on mesenchymal stem cells used in cardiac tissue regeneration」主題。共同形成了獨特的指紋。

  • 引用此

    Lin, Y. H., Kang, L., Feng, W. H., Cheng, T. L., Tsai, W. C., Huang, H. T., Lee, H. C., & Chen, C. H. (2020). Effects of lipids and lipoproteins on mesenchymal stem cells used in cardiac tissue regeneration. International journal of molecular sciences, 21(13), 1-17. [4770]. https://doi.org/10.3390/ijms21134770