Effects of mechanical stress/strain and estrogen on cancellous bone structure predicted by fuzzy decision

Zong Ping Luo, Lin Zhang, Russell T. Turner, Kai Nan An

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

A theoretical model was developed on the basis of fuzzy decision to predict cancellous bone structure following changes in mechanical stress/strain and estrogen. The model was validated experimentally by simulation of the normal structure of a rat distal femur, and further used to predict the structural alterations following ovarian hormone deficiency. The results show that net bone resorption after ovariectomy occurs in the metaphysis at locations where trabecula were subjected to the lowest mechanical stress/strain. These findings, consistent with experimental results, suggest that estrogen deficiency increase the mechanostat set point at which bone cells perceive mechanical stress/strain. Additionally, the results show that changes in bone architecture which are due to alterations in bone remodeling can be simulated by fuzzy decision without precise mathematical description, and multiple factors can also be readily incorporated into the model.

原文English
頁(從 - 到)344-351
頁數8
期刊IEEE Transactions on Biomedical Engineering
47
發行號3
DOIs
出版狀態Published - 2000

All Science Journal Classification (ASJC) codes

  • 生物醫學工程

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