Effects of multiple virus coinfections on disease progression in HIV-positive patients

Biehuoy Shieh, Ming Jen Chang, Wen Chien Ko, Eng Jun Chen, Jaw Ching Wu, Chia Fang Lee, Ting Tsung Chang, Ching Li

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)


Objective: Since virus infections in AIDS patients are mostly inevitable and as they frequently cause disease deterioration and therapeutic failures, a comprehensive investigation was made of the influence of the coinfections of 9 well-known viruses on disease progression in patients infected with human immunodeficiency virus type 1 (HIV). Methods: A cross-sectional study of 62 HIV-positive patients was conducted to correlate the prevalence rates for the 9 viruses with the alanine aminotransferase (ALT) levels and CD4 cell counts of the patients. Results: The rates of HIV-positive patients infected with the 9 viruses are significantly higher than those of the control groups. Furthermore, almost one third of the patients in the studied group was coinfected with transfusion-transmitted virus (TTV) and manifested significantly higher ALT levels (p = 0.020), and these were raised further if coinfection with TTV and human hepatitis C virus had occurred (p = 0.010). By analyzing CD4 cell counts, the only significant effect on AIDS progression which could be detected was coinfection with human herpesvirus 8. Conclusion: This result confirmed that immune-suppressed persons are more vulnerable to common virus infections. Unlike hepatitis B or C virus, TTV seems to accelerate the progression of chronic hepatitis in HIV-infected patients.

頁(從 - 到)105-113
出版狀態Published - 2003

All Science Journal Classification (ASJC) codes

  • 病毒學
  • 傳染性疾病


深入研究「Effects of multiple virus coinfections on disease progression in HIV-positive patients」主題。共同形成了獨特的指紋。