Effects of sebum on drug transport across the human stratum corneum in vivo

Jui-Chen Tsai, Cheng-Chan Lu, M. K. Lin, J. W. Guo, H. M. Sheu

研究成果: Article

11 引文 斯高帕斯(Scopus)

摘要

The objective of this study was to investigate the effect of sebum on drug transport across the human stratum corneum (SC) in vivo for two model compounds, 4-cyanophenol (CP) and cimetidine (CM), of different lipophilicity and molecular size by utilizing noninvasive tape-stripping techniques, in conjunction with an unsteady-state diffusion model for data analysis. The results demonstrated that the SC permeability of the relatively hydrophilic CM on the forehead may be as much as four times the permeability on the forearm. The administration of sebum supplementation to the forearm increased the SC permeability of CM more than threefold, but did not have the same effect with regard to CP. Removal of sebum from the forehead demonstrated a small but significant effect (-22%) on the SC permeability of CM. The presence of sebum on the forehead or forearm increased the diffusion of both molecules, but the effect on partition varied between sites and drugs. The change in the SC permeability of the relatively hydrophilic drug using sebum treatment may be attributable to the altered barrier function of the SC due to the disordering structures of the intercellular lipid molecules.

原文English
頁(從 - 到)124-132
頁數9
期刊Skin Pharmacology and Physiology
25
發行號3
DOIs
出版狀態Published - 2012 四月 1

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Dermatology

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