Efficacy and safety of renal denervation for patients with uncontrolled hypertension in taiwan: 3-year results from the global symplicity registry-taiwan (GSR-Taiwan)

Chih Kuo Lee, Tzung Dau Wang, Ying Hsiang Lee, Martin Fahy, Cheng Han Lee, Shih Hsien Sung, Hsien Li Kao, Yen Wen Wu, Tsung Hsien Lin

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background: It is unclear whether renal denervation (RDN) can safely result in blood pressure (BP) reductions in Asian hypertensive patients and whether such reductions would be sustainable. The study is to assess the safety and efficacy of RDN achieved by either main renal artery ablation using the Symplicity Flex™ catheter or main plus branch renal artery ablations using the Symplicity Spyral™ catheter in Taiwanese uncontrolled hypertensive patients enrolled in the Global SYMPLICITY Registry (GSR) with 3 years of follow-up. Methods: The GSR is a prospective, open-label, and all-comer registry to evaluate the safety and effectiveness of RDN in patients with uncontrolled hypertension worldwide. Results: Among 26 patients enrolled (mean age, 59.1 ± 13.8 years), 8 were treated with the Symplicity Flex™ catheter, and 18 were treated with the Symplicity Spyral™ catheter. Baseline office systolic BP was 168.2 ± 19.8 mmHg and diastolic BP was 89.0 ± 14.3 mmHg. Office BP reductions following RDN were sustained throughout the follow-up periods of up to 3 years in the Symplicity Flex™ group and 2 years in the Symplicity Spyral™ group. In the Symplicity Flex™ group, the office systolic BP reductions were 14.9 ± 14.7 mmHg and 29.7 ± 25.9 mmHg at 3 months and 3 years, respectively (both p < 0.05 from baseline). In the Symplicity Spyral™ group, the office systolic BP reductions were 21.2 ± 28.7 mmHg and 42.4 ± 10.7 mmHg at 3 months and 2 years, respectively (both p < 0.05 from baseline). There were no significant changes in heart rate or antihypertensive medication classes. Three protocol-defined adverse events occurred in 2 patients, including new-onset end-stage renal disease, stroke, and hospitalization for new-onset heart failure. Conclusions: Given the susceptibility of Asian populations to hypertension, RDN, as a safe antihypertensive procedure with long-lasting BP-lowering effects, could reliably serve as an alternative or complementary BP-lowering strategy for patients with uncontrolled hypertension in Taiwan and other Asian countries.

原文English
頁(從 - 到)618-626
頁數9
期刊Acta Cardiologica Sinica
35
發行號6
DOIs
出版狀態Published - 2019

All Science Journal Classification (ASJC) codes

  • 心臟病學與心血管醫學

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