Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues

Shih Heng Chen, Hui Wen Yao, Wen Yen Huang, Kuei Sen Hsu, Huan Yao Lei, Ai Li Shiau, Shun Hua Chen

研究成果: Article同行評審

32 引文 斯高帕斯(Scopus)

摘要

For decades, numerous ex vivo studies have documented that latent herpes simplex virus (HSV) reactivates efficiently from ganglia, but rarely from the central nervous systems (CNS), of mice when assayed by mincing tissues before expiant culture, despite the presence of viral genomes in both sites. Here we show that 88% of mouse brain stems reactivated latent virus when they were dissociated into cell suspensions before ex vivo explant culture. The efficient reactivation of HSV from the mouse CNS was demonstrated with more than one viral strain, viral serotype, and mouse strain, further indicating that the CNS can be an authentic latency site for HSV with the potential to cause recurrent disease.

原文English
頁(從 - 到)12387-12392
頁數6
期刊Journal of Virology
80
發行號24
DOIs
出版狀態Published - 2006 十二月

All Science Journal Classification (ASJC) codes

  • 微生物學
  • 免疫學
  • 昆蟲科學
  • 病毒學

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