Efficient 1H nuclear magnetic resonance method for improved quality control analyses of Ginkgo constituents

Chia Ying Li, Chun Hua Lin, Chia Che Wu, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

42 引文 斯高帕斯(Scopus)

摘要

We developed an analytical method using 1H nuclear magnetic resonance (NMR) spectrometry to resolve analytical problems with Ginkgo. After a simple hydrolysis step, an NMR analysis of the terpene trilactone H-12 signals and the flavonol aglycone H-2′ (or H-2′/6′ for kaempferol) signals was performed. By comparing the solvent effects on the resolution of these signals, methanol-d4-benzene-d6 (65:35) was selected as the optimal 1H NMR solvent. The amounts of terpene lactones and flavonol aglycones in various commercial Ginkgo products and Ginkgo leaves were determined. This newly developed 1H NMR method enables the simultaneous analysis of terpene trilactones and flavonols and allows simple, rapid quantification of these compounds in pharmaceutical Ginkgo preparations.

原文English
頁(從 - 到)3721-3725
頁數5
期刊Journal of Agricultural and Food Chemistry
52
發行號12
DOIs
出版狀態Published - 2004 六月 16

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 農業與生物科學 (全部)

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