Electrical characterization of single HeLa cell using 2D simulation and spectroscopy measurement

M. H. Wang, M. K. Chen, L. S. Jang

研究成果: Conference contribution

2 引文 斯高帕斯(Scopus)

摘要

The electrical properties of single cells provide fundamental insights into their pathological condition and are therefore of immense interest to medical practitioners. Accordingly, this study captures single HeLa cells using a microfluidic device and then measures their impedance properties using a commercial impedance spectroscopy system. The experimental system is modeled by an equivalent electrical circuit and COMSOL simulations are then performed to establish the conductivity, permittivity and impedance of single HeLa cells under various operational frequencies and voltages. At an operational voltage of 0.2 V, the maximum deviation between the experimental and simulation results for the magnitude and phase of the HeLa cell impedance is found to be 9.5% and 4.2%, respectively. In general, both sets of results show that the conductivity and permittivity of single HeLa cells increase with an increasing operational voltage. Moreover, an increasing frequency is found to increase the conductivity of HeLa cells at all values of the operational voltage, but to reduce the permittivity for operational voltages in the range 0.6-1.0 V.

原文English
主出版物標題2008 Cairo International Biomedical Engineering Conference, CIBEC 2008
DOIs
出版狀態Published - 2008 十二月 1
事件2008 Cairo International Biomedical Engineering Conference, CIBEC 2008 - Cairo, Egypt
持續時間: 2008 十二月 182008 十二月 20

出版系列

名字2008 Cairo International Biomedical Engineering Conference, CIBEC 2008

Other

Other2008 Cairo International Biomedical Engineering Conference, CIBEC 2008
國家Egypt
城市Cairo
期間08-12-1808-12-20

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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    Wang, M. H., Chen, M. K., & Jang, L. S. (2008). Electrical characterization of single HeLa cell using 2D simulation and spectroscopy measurement. 於 2008 Cairo International Biomedical Engineering Conference, CIBEC 2008 [4786114] (2008 Cairo International Biomedical Engineering Conference, CIBEC 2008). https://doi.org/10.1109/CIBEC.2008.4786114