Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Ying Chi Chen, Yi Ting Li, Chin Lai Lee, Yen Ting Kuo, Chia Lun Ho, Wei Che Lin, Ming Chien Hsu, Xizi Long, Jia Sin Chen, Wei Peng Li, Chia Hao Su, Akihiro Okamoto, Chen Sheng Yeh

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)


Dynamic therapies have potential in cancer treatments but have limitations in efficiency and penetration depth. Here a membrane-integrated liposome (MIL) is created to coat titanium dioxide (TiO2) nanoparticles to enhance electron transfer and increase radical production under low-dose X-ray irradiation. The exoelectrogenic Shewanella oneidensis MR-1 microorganism presents an innate capability for extracellular electron transfer (EET). An EET-mimicking photocatalytic system is created by coating the TiO2 nanoparticles with the MIL, which significantly enhances superoxide anions generation under low-dose (1 Gy) X-ray activation. The c-type cytochromes-constructed electron channel in the membrane mimics electron transfer to surrounding oxygen. Moreover, the hole transport in the valence band is also observed for water oxidation to produce hydroxyl radicals. The TiO2@MIL system is demonstrated against orthotopic liver tumours in vivo.

頁(從 - 到)1492-1501
期刊Nature Nanotechnology
出版狀態Published - 2023 12月

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 原子與分子物理與光學
  • 生物醫學工程
  • 一般材料科學
  • 凝聚態物理學
  • 電氣與電子工程


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