Electrokinetic trapping and surface enhanced Raman scattering detection of biomolecules using optofluidic device integrated with a microneedles array

Yu Luen Deng, Yi-Je Juang

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

In this study, microneedles which possess sharp tips were utilized to trap and detect the biomolecules. Owing to the large curvature, the tips of the microneedles created a substantially high gradient of electric field under the non-uniform electric field which served as not only the trapping sites but also the substrate for surface enhanced Raman scattering (SERS). Separation of polystyrene microparticles with different sizes and two kinds of biomolecules (Staphylococcus aureus (S. aureus) and the red blood cells (RBCs)) were demonstrated. Moreover, in situ detection of S. aureus was performed immediately after separation was completed. The results showed that, after 15 s of sample collection, the Raman signals of S. aureus were detected and greatly enhanced through SERS effect.

原文English
文章編號014111
期刊Biomicrofluidics
7
發行號1
DOIs
出版狀態Published - 2013 二月 4

All Science Journal Classification (ASJC) codes

  • 分子生物學
  • 材料科學(全部)
  • 遺傳學
  • 凝聚態物理學
  • 物理與理論化學

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