Electrolyte abnormalities and laboratory findings in patients with out-of-hospital cardiac arrest who have kidney disease

Chih-Hao Lin, Yi-Fang Tu, Wen Chu Chiang, Shyu Yu Wu, Ying-Hsin Chang, Chih-Hsien Chi

研究成果: Article

11 引文 (Scopus)

摘要

Purposes: Although electrolyte abnormalities have been generally considered the major cause of out-of-hospital cardiac arrest (OHCA) in patients with kidney disease (KD), this association has never been prospectively validated. Methods: A prospective, observational study was conducted in a tertiary university hospital between January 2008 and December 2009. The study sample consisted of consecutively admitted patients with nontraumatic OHCA. Based on the estimated glomerular filtration rate (eGFR, unit: milliliters per minute per 1.73 m2), the enrollees were divided into 3 groups: group A (normal kidney function or mild KD; eGFR, 60.0), group B (moderate KD; eGFR between 15.0 and 59.9), and group C (severe KD; eGFR<15.0 or on dialysis). The laboratory findings of the groups were compared. Two-tailed P values less than.005 were considered significant. Results: Two hundred thirty-four enrollees (137 were male) were divided into 3 groups: group A (n = 51; 21.8%), group B (n = 128; 54.7%), and group C (n = 55; 23.5%). Compared with the other 2 groups, group C presented significantly higher serum potassium and magnesium and lower pH and hemoglobin level (all P <.005). After stratifications of the significant variables, a post hoc analysis revealed that group C presented significantly higher incidences of hypermagnesemia (Mg > 2.5 mmol/L) and severe hyperkalemia (K > 6.5 mmol/L) (both P <.005) than the other 2 groups. The odds ratios of the incidence of severe hyperkalemia in group C was 3.37 (95% confidence intervals, 1.46-7.77) compared with group A (50.9% vs 23.5%, P <.005). Conclusions: Severe hyperkalemia is common in patients with OHCA who have severe KD and should be considered during resuscitation for these patients.

原文English
頁(從 - 到)487-493
頁數7
期刊American Journal of Emergency Medicine
31
發行號3
DOIs
出版狀態Published - 2013 三月 1

指紋

Out-of-Hospital Cardiac Arrest
Kidney Diseases
Electrolytes
Hyperkalemia
Glomerular Filtration Rate
Tertiary Care Centers
Resuscitation
Observational Studies
Odds Ratio
Prospective Studies
Confidence Intervals
Kidney
Incidence

All Science Journal Classification (ASJC) codes

  • Emergency Medicine

引用此文

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title = "Electrolyte abnormalities and laboratory findings in patients with out-of-hospital cardiac arrest who have kidney disease",
abstract = "Purposes: Although electrolyte abnormalities have been generally considered the major cause of out-of-hospital cardiac arrest (OHCA) in patients with kidney disease (KD), this association has never been prospectively validated. Methods: A prospective, observational study was conducted in a tertiary university hospital between January 2008 and December 2009. The study sample consisted of consecutively admitted patients with nontraumatic OHCA. Based on the estimated glomerular filtration rate (eGFR, unit: milliliters per minute per 1.73 m2), the enrollees were divided into 3 groups: group A (normal kidney function or mild KD; eGFR, 60.0), group B (moderate KD; eGFR between 15.0 and 59.9), and group C (severe KD; eGFR<15.0 or on dialysis). The laboratory findings of the groups were compared. Two-tailed P values less than.005 were considered significant. Results: Two hundred thirty-four enrollees (137 were male) were divided into 3 groups: group A (n = 51; 21.8{\%}), group B (n = 128; 54.7{\%}), and group C (n = 55; 23.5{\%}). Compared with the other 2 groups, group C presented significantly higher serum potassium and magnesium and lower pH and hemoglobin level (all P <.005). After stratifications of the significant variables, a post hoc analysis revealed that group C presented significantly higher incidences of hypermagnesemia (Mg > 2.5 mmol/L) and severe hyperkalemia (K > 6.5 mmol/L) (both P <.005) than the other 2 groups. The odds ratios of the incidence of severe hyperkalemia in group C was 3.37 (95{\%} confidence intervals, 1.46-7.77) compared with group A (50.9{\%} vs 23.5{\%}, P <.005). Conclusions: Severe hyperkalemia is common in patients with OHCA who have severe KD and should be considered during resuscitation for these patients.",
author = "Chih-Hao Lin and Yi-Fang Tu and Chiang, {Wen Chu} and Wu, {Shyu Yu} and Ying-Hsin Chang and Chih-Hsien Chi",
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T1 - Electrolyte abnormalities and laboratory findings in patients with out-of-hospital cardiac arrest who have kidney disease

AU - Lin, Chih-Hao

AU - Tu, Yi-Fang

AU - Chiang, Wen Chu

AU - Wu, Shyu Yu

AU - Chang, Ying-Hsin

AU - Chi, Chih-Hsien

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Purposes: Although electrolyte abnormalities have been generally considered the major cause of out-of-hospital cardiac arrest (OHCA) in patients with kidney disease (KD), this association has never been prospectively validated. Methods: A prospective, observational study was conducted in a tertiary university hospital between January 2008 and December 2009. The study sample consisted of consecutively admitted patients with nontraumatic OHCA. Based on the estimated glomerular filtration rate (eGFR, unit: milliliters per minute per 1.73 m2), the enrollees were divided into 3 groups: group A (normal kidney function or mild KD; eGFR, 60.0), group B (moderate KD; eGFR between 15.0 and 59.9), and group C (severe KD; eGFR<15.0 or on dialysis). The laboratory findings of the groups were compared. Two-tailed P values less than.005 were considered significant. Results: Two hundred thirty-four enrollees (137 were male) were divided into 3 groups: group A (n = 51; 21.8%), group B (n = 128; 54.7%), and group C (n = 55; 23.5%). Compared with the other 2 groups, group C presented significantly higher serum potassium and magnesium and lower pH and hemoglobin level (all P <.005). After stratifications of the significant variables, a post hoc analysis revealed that group C presented significantly higher incidences of hypermagnesemia (Mg > 2.5 mmol/L) and severe hyperkalemia (K > 6.5 mmol/L) (both P <.005) than the other 2 groups. The odds ratios of the incidence of severe hyperkalemia in group C was 3.37 (95% confidence intervals, 1.46-7.77) compared with group A (50.9% vs 23.5%, P <.005). Conclusions: Severe hyperkalemia is common in patients with OHCA who have severe KD and should be considered during resuscitation for these patients.

AB - Purposes: Although electrolyte abnormalities have been generally considered the major cause of out-of-hospital cardiac arrest (OHCA) in patients with kidney disease (KD), this association has never been prospectively validated. Methods: A prospective, observational study was conducted in a tertiary university hospital between January 2008 and December 2009. The study sample consisted of consecutively admitted patients with nontraumatic OHCA. Based on the estimated glomerular filtration rate (eGFR, unit: milliliters per minute per 1.73 m2), the enrollees were divided into 3 groups: group A (normal kidney function or mild KD; eGFR, 60.0), group B (moderate KD; eGFR between 15.0 and 59.9), and group C (severe KD; eGFR<15.0 or on dialysis). The laboratory findings of the groups were compared. Two-tailed P values less than.005 were considered significant. Results: Two hundred thirty-four enrollees (137 were male) were divided into 3 groups: group A (n = 51; 21.8%), group B (n = 128; 54.7%), and group C (n = 55; 23.5%). Compared with the other 2 groups, group C presented significantly higher serum potassium and magnesium and lower pH and hemoglobin level (all P <.005). After stratifications of the significant variables, a post hoc analysis revealed that group C presented significantly higher incidences of hypermagnesemia (Mg > 2.5 mmol/L) and severe hyperkalemia (K > 6.5 mmol/L) (both P <.005) than the other 2 groups. The odds ratios of the incidence of severe hyperkalemia in group C was 3.37 (95% confidence intervals, 1.46-7.77) compared with group A (50.9% vs 23.5%, P <.005). Conclusions: Severe hyperkalemia is common in patients with OHCA who have severe KD and should be considered during resuscitation for these patients.

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