Elevated low-density lipoprotein in Alzheimer's disease correlates with brain aβ 1-42 levels

Yu Min Kuo, Mark R. Emmerling, Charles L. Bisgaier, Arnold D. Essenburg, Heather C. Lampert, Denise Drumm, Alex E. Roher

研究成果: Article同行評審

283 引文 斯高帕斯(Scopus)

摘要

Sera obtained in the immediate postmortem from 100 individuals, 64 neuropathologically diagnosed Alzheimer's disease (AD) cases and 36 nondemented controls, were analyzed for cholesterol, lipoproteins, apolipoproteins (Ape), and triglycerides. All individuals were ApoE genotyped, and the amounts of Aβ (N-40 and N-42) in cerebral cortex of AD and control subjects were determined. When compared to controls, AD individuals had significantly higher LDL cholesterol (P = 0.006), ApoB (P = 0.018), Aβ N-40 (P = 0.024) and Aβ N-42 (P < 0.001), and significantly lower HDL cholesterol (P = 0.040). There were positive correlations between the levels of serum total cholesterol (r = 0.359, P = 0.004), LDL cholesterol (r = 0.328, P = 0.008), and ApoB (r = 0.395, P = 0.001) to the amount of Aβ N-42 in AD brains, but not to Aβ N-40. These correlations were independent of ApoE genotype and were not seen in the control group. The present results suggest for the first time that elevated serum cholesterol, especially in the form of LDL, influences the expression of AD-related pathology.

原文English
頁(從 - 到)711-715
頁數5
期刊Biochemical and Biophysical Research Communications
252
發行號3
DOIs
出版狀態Published - 1998 十一月 27

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物化學
  • 分子生物學
  • 細胞生物學

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