Elevated serum matrix metalloproteinase-3 and -7 in H. Pylori-related gastric cancer can be biomarkers correlating with a poor survival

Yi Chun Yeh, Bor Shyang Sheu, Hsiu Chi Cheng, Yen Lin Wang, Hsiao Bai Yang, Jiunn Jong Wu

研究成果: Article

49 引文 (Scopus)

摘要

Background: Helicobacter pylori (H. pylori) infection up-regulates the expression of matrix metalloproteinases (MMPs), which may be involved in chronic inflammation, ulceration, and even cancer development. This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer. Method: Two hundred one patients, 28 with H. pylori-negative gastritis and 173 with different H. pylori-positive gastrointestinal diseases (46 gastritis, 43 duodenal ulcers, 29 gastric ulcers, and 55 gastric cancers) were assessed for serum MMP-3, -7, and -9 titers by enzyme-linked immunosorbent assay and validated to their correlations with the different clinical features and survival of patients with H. pylori-positive gastric cancer. Results: Among the H. pylori-infected subjects, gastric cancer patients had higher serum levels of MMP-3 and MMP-7 than those with duodenal ulcer and gastritis (P < 0.05). For gastric cancer patients, concomitant elevated MMP-3 (>14 ng/ml) and MMP-7 (>4.5 ng/ml) independently correlated with lymph node invasion (P < 0.05) and could be predictive to have shorter 2- or 5-year survivals (log rank test, P = 0.006). Conclusion: Concomitant elevations of MMP-3 and MMP-7 serum levels in the H. pylori-infected gastric cancer patients could serve as potential biomarkers to correlate with poor survival.

原文English
頁(從 - 到)1649-1657
頁數9
期刊Digestive Diseases and Sciences
55
發行號6
DOIs
出版狀態Published - 2010 六月 1

指紋

Matrix Metalloproteinase 7
Matrix Metalloproteinase 3
Pylorus
Helicobacter pylori
Stomach Neoplasms
Biomarkers
Survival
Serum
Gastritis
Duodenal Ulcer
Gastrointestinal Diseases
Helicobacter Infections
Stomach Ulcer
Matrix Metalloproteinases
Up-Regulation
Lymph Nodes
Enzyme-Linked Immunosorbent Assay
Inflammation

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

引用此文

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title = "Elevated serum matrix metalloproteinase-3 and -7 in H. Pylori-related gastric cancer can be biomarkers correlating with a poor survival",
abstract = "Background: Helicobacter pylori (H. pylori) infection up-regulates the expression of matrix metalloproteinases (MMPs), which may be involved in chronic inflammation, ulceration, and even cancer development. This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer. Method: Two hundred one patients, 28 with H. pylori-negative gastritis and 173 with different H. pylori-positive gastrointestinal diseases (46 gastritis, 43 duodenal ulcers, 29 gastric ulcers, and 55 gastric cancers) were assessed for serum MMP-3, -7, and -9 titers by enzyme-linked immunosorbent assay and validated to their correlations with the different clinical features and survival of patients with H. pylori-positive gastric cancer. Results: Among the H. pylori-infected subjects, gastric cancer patients had higher serum levels of MMP-3 and MMP-7 than those with duodenal ulcer and gastritis (P < 0.05). For gastric cancer patients, concomitant elevated MMP-3 (>14 ng/ml) and MMP-7 (>4.5 ng/ml) independently correlated with lymph node invasion (P < 0.05) and could be predictive to have shorter 2- or 5-year survivals (log rank test, P = 0.006). Conclusion: Concomitant elevations of MMP-3 and MMP-7 serum levels in the H. pylori-infected gastric cancer patients could serve as potential biomarkers to correlate with poor survival.",
author = "Yeh, {Yi Chun} and Sheu, {Bor Shyang} and Cheng, {Hsiu Chi} and Wang, {Yen Lin} and Yang, {Hsiao Bai} and Wu, {Jiunn Jong}",
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Elevated serum matrix metalloproteinase-3 and -7 in H. Pylori-related gastric cancer can be biomarkers correlating with a poor survival. / Yeh, Yi Chun; Sheu, Bor Shyang; Cheng, Hsiu Chi; Wang, Yen Lin; Yang, Hsiao Bai; Wu, Jiunn Jong.

於: Digestive Diseases and Sciences, 卷 55, 編號 6, 01.06.2010, p. 1649-1657.

研究成果: Article

TY - JOUR

T1 - Elevated serum matrix metalloproteinase-3 and -7 in H. Pylori-related gastric cancer can be biomarkers correlating with a poor survival

AU - Yeh, Yi Chun

AU - Sheu, Bor Shyang

AU - Cheng, Hsiu Chi

AU - Wang, Yen Lin

AU - Yang, Hsiao Bai

AU - Wu, Jiunn Jong

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background: Helicobacter pylori (H. pylori) infection up-regulates the expression of matrix metalloproteinases (MMPs), which may be involved in chronic inflammation, ulceration, and even cancer development. This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer. Method: Two hundred one patients, 28 with H. pylori-negative gastritis and 173 with different H. pylori-positive gastrointestinal diseases (46 gastritis, 43 duodenal ulcers, 29 gastric ulcers, and 55 gastric cancers) were assessed for serum MMP-3, -7, and -9 titers by enzyme-linked immunosorbent assay and validated to their correlations with the different clinical features and survival of patients with H. pylori-positive gastric cancer. Results: Among the H. pylori-infected subjects, gastric cancer patients had higher serum levels of MMP-3 and MMP-7 than those with duodenal ulcer and gastritis (P < 0.05). For gastric cancer patients, concomitant elevated MMP-3 (>14 ng/ml) and MMP-7 (>4.5 ng/ml) independently correlated with lymph node invasion (P < 0.05) and could be predictive to have shorter 2- or 5-year survivals (log rank test, P = 0.006). Conclusion: Concomitant elevations of MMP-3 and MMP-7 serum levels in the H. pylori-infected gastric cancer patients could serve as potential biomarkers to correlate with poor survival.

AB - Background: Helicobacter pylori (H. pylori) infection up-regulates the expression of matrix metalloproteinases (MMPs), which may be involved in chronic inflammation, ulceration, and even cancer development. This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer. Method: Two hundred one patients, 28 with H. pylori-negative gastritis and 173 with different H. pylori-positive gastrointestinal diseases (46 gastritis, 43 duodenal ulcers, 29 gastric ulcers, and 55 gastric cancers) were assessed for serum MMP-3, -7, and -9 titers by enzyme-linked immunosorbent assay and validated to their correlations with the different clinical features and survival of patients with H. pylori-positive gastric cancer. Results: Among the H. pylori-infected subjects, gastric cancer patients had higher serum levels of MMP-3 and MMP-7 than those with duodenal ulcer and gastritis (P < 0.05). For gastric cancer patients, concomitant elevated MMP-3 (>14 ng/ml) and MMP-7 (>4.5 ng/ml) independently correlated with lymph node invasion (P < 0.05) and could be predictive to have shorter 2- or 5-year survivals (log rank test, P = 0.006). Conclusion: Concomitant elevations of MMP-3 and MMP-7 serum levels in the H. pylori-infected gastric cancer patients could serve as potential biomarkers to correlate with poor survival.

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U2 - 10.1007/s10620-009-0926-x

DO - 10.1007/s10620-009-0926-x

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JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

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