Elevated serum matrix metalloproteinase-3 and -7 in H. Pylori-related gastric cancer can be biomarkers correlating with a poor survival

Yi Chun Yeh, Bor Shyang Sheu, Hsiu Chi Cheng, Yen Lin Wang, Hsiao Bai Yang, Jiunn Jong Wu

研究成果: Article同行評審

63 引文 斯高帕斯(Scopus)

摘要

Background: Helicobacter pylori (H. pylori) infection up-regulates the expression of matrix metalloproteinases (MMPs), which may be involved in chronic inflammation, ulceration, and even cancer development. This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer. Method: Two hundred one patients, 28 with H. pylori-negative gastritis and 173 with different H. pylori-positive gastrointestinal diseases (46 gastritis, 43 duodenal ulcers, 29 gastric ulcers, and 55 gastric cancers) were assessed for serum MMP-3, -7, and -9 titers by enzyme-linked immunosorbent assay and validated to their correlations with the different clinical features and survival of patients with H. pylori-positive gastric cancer. Results: Among the H. pylori-infected subjects, gastric cancer patients had higher serum levels of MMP-3 and MMP-7 than those with duodenal ulcer and gastritis (P < 0.05). For gastric cancer patients, concomitant elevated MMP-3 (>14 ng/ml) and MMP-7 (>4.5 ng/ml) independently correlated with lymph node invasion (P < 0.05) and could be predictive to have shorter 2- or 5-year survivals (log rank test, P = 0.006). Conclusion: Concomitant elevations of MMP-3 and MMP-7 serum levels in the H. pylori-infected gastric cancer patients could serve as potential biomarkers to correlate with poor survival.

原文English
頁(從 - 到)1649-1657
頁數9
期刊Digestive Diseases and Sciences
55
發行號6
DOIs
出版狀態Published - 2010 6月

All Science Journal Classification (ASJC) codes

  • 生理學
  • 消化內科

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